Assessment of cumulative evidence on genetic associations : interim guidelines

Details

• Alternative Title:
  International journal of epidemiology
• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.). Office of Public Health Genomics.
• Description:
  Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors
• Subjects:
  Epidemiologic Studies Evaluation Studies As Topic Evidence-Based Medicine Female Genetic Heterogeneity Genetic Predisposition To Disease Guidelines As Topic Heterozygote Detection Humans Male Sensitivity And Specificity

  More +
• Source:
  International journal of epidemiology. 2008; 37(1):120-32.
• Pubmed ID:
  17898028
• Document Type:
  Journal Article
• Volume:
  37
• Issue:
  1
• Collection(s):
  Guidelines and Recommendations
• Main Document Checksum:
  urn:sha-512:b4879cfd4053805052b167dd8d96a021310f52b10a8a6177d46e10543d1a28a6d12ee502758aaa02cd7b9dbd0bec203ba0549bfd5c01b06bbf9c944458bf6c4f
• Download URL:
  https://stacks.cdc.gov/view/cdc/7554/cdc_7554_DS1.pdf
• File Type:
  [PDF - 364.73 KB ]