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Neighborhood assets and early pregnancy cardiometabolic risk factors
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1 2019
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Source: Paediatr Perinat Epidemiol. 33(1):79-87
[PDF-1.69 MB]
Details:
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Alternative Title:Paediatr Perinat Epidemiol
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Personal Author:
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Description:Background:
Pre-pregnancy cardiometabolic risk factors are associated with increased risks of adverse pregnancy outcomes. Neighborhood features may reflect pre-pregnancy exposures that contribute to poor cardiometabolic health before pregnancy and may contribute to racial disparities in pregnancy outcomes.
Methods:
Early pregnancy measurements from 1,504 women enrolled in the Prenatal Exposures and Preeclampsia Prevention study were linked to a 2000 Census-based measure of neighborhood socioeconomic status and commercial data (food, alcohol, and retail density) during 1997–2001. Multilevel random-intercept linear regression was used to separately estimate the association between levels of neighborhood assets (low, mid-low, mid-high, high) and C-reactive protein (CRP), systolic blood pressure (SBP), and body mass index (BMI) in cross-sectional analyses. Low neighborhood assets have high-poverty/low-retail, whereas, high neighborhood assets have low-poverty/high-retail. Models were adjusted for individual-level factors (age and race), and we assessed effect modification by race.
Results:
Low compared with high neighborhood assets were associated with higher BMI (β 1.95 kg/m2, 95% CI 0.89, 3.00), after adjusting for individual-level covariates. After adjusting for BMI and other covariates, low compared with high assets were associated with higher CRP concentrations (β 0.20 ng/mL, 95% CI 0.01, 0.39). Neighborhood assets were not associated with SBP. Race did not modify the association between neighborhood assets and cardiometabolic risk factors.
Conclusions:
Early pregnancy adiposity is related to neighborhood features independent of individual factors. Further, inflammation beyond accounting for adiposity is related to neighborhood features. Strategies that address neighborhood assets during pre-conception and interconception may be promising approaches to improve pre-pregnancy health.
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Pubmed ID:30632180
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Pubmed Central ID:PMC6353674
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Funding:U01 CE001630/CE/NCIPC CDC HHSUnited States/ ; P01 HD030367/HD/NICHD NIH HHSUnited States/ ; 16SFRN27810001/AHA/American Heart Association-American Stroke AssociationUnited States/ ; AHA 16SFRN28930000/American Heart AssociationInternational/ ; AHA16SFRN27810001/American Heart AssociationInternational/
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