Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies : recommendations of the advisory committee on immunization practices

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Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies : recommendations of the advisory committee on immunization practices

March 19, 2010
By National Center for Emerging and Zoonotic Infectious Diseases (proposed) ...
Source: MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control. 2010; 59(RR-2):1-9.

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English

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Alternative Title:

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control
Corporate Authors:

National Center for Emerging and Zoonotic Infectious Diseases (proposed) ; United States. Advisory Committee on Immunization Practices.

National Center for Emerging and Zoonotic Infectious Diseases (proposed) ; United States. Advisory Committee on Immunization Practices. Less -
Description:

This report summarizes new recommendation and updates previous recommendations of the Advisory Committee on Immunization Practices (ACIP) for postexposure prophylaxis (PEP) to prevent human rabies (CDC. Human rabies prevention---United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR 2008;57[No. RR-3]). Previously, ACIP recommended a 5-dose rabies vaccination regimen with human diploid cell vaccine (HDCV) or purified chick embryo cell vaccine (PCECV). These new recommendations reduce the number of vaccine doses to four. The reduction in doses recommended for PEP was based in part on evidence from rabies virus pathogenesis data, experimental animal work, clinical studies, and epidemiologic surveillance. These studies indicated that 4 vaccine doses in combination with rabies immune globulin (RIG) elicited adequate immune responses and that a fifth dose of vaccine did not contribute to more favorable outcomes. For persons previously unvaccinated with rabies vaccine, the reduced regimen of 4 1-mL doses of HDCV or PCECV should be administered intramuscularly. The first dose of the 4-dose course should be administered as soon as possible after exposure (day 0). Additional doses then should be administered on days 3, 7, and 14 after the first vaccination. ACIP recommendations for the use of RIG remain unchanged. For persons who previously received a complete vaccination series (pre- or postexposure prophylaxis) with a cell-culture vaccine or who previously had a documented adequate rabies virus-neutralizing antibody titer following vaccination with noncell-culture vaccine, the recommendation for a 2-dose PEP vaccination series has not changed. Similarly, the number of doses recommended for persons with altered immunocompetence has not changed; for such persons, PEP should continue to comprise a 5-dose vaccination regimen with 1 dose of RIG. Recommendations for pre-exposure prophylaxis also remain unchanged, with 3 doses of vaccine administered on days 0, 7, and 21 or 28. Prompt rabies PEP combining wound care, infiltration of RIG into and around the wound, and multiple doses of rabies cell-culture vaccine continue to be highly effective in preventing human rabies.
Subjects:

[+]

Humans Immunization Schedule Immunocompetence Immunoglobulins Injections, Intramuscular Rabies Rabies Vaccines Rabies Virus
Source:

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control. 2010; 59(RR-2):1-9.
Pubmed ID:

20300058
Document Type:

Journal Issue
Volume:

59
Collection(s):

Advisory Committee on Immunization Practices (ACIP) Morbidity and Mortality Weekly Report (MMWR) Guidelines and Recommendations
Main Document Checksum:

[+]

urn:sha256:3cd08e2e7977b50cc10da06ef61fea30d2eb500122bff2c4ae93202cc6df09d2
Download URL:

https://stacks.cdc.gov/view/cdc/7224/cdc_7224_DS1.pdf
File Type:

No Additional Files

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Rabies prevention--United States, 1991 : recommendations of the Immunization Practices Advisory Committee (ACIP)

[PDF - 235.17 KB]

:

Centers for Disease Control (U.S.). Immunization Practices Advisory Committee.

March 22, 1991 | MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control. 1991; 40(RR-3):1-19.

Description:

These revised recommendations of the Immunization Practices Advisory Committee (ACIP) on rabies prevention update the previous recommendations (MMWR 1...

Status:

superseded

File Type:

[PDF - 235.17 KB]

File Type:

[PDF - 235.17 KB]
Human rabies prevention -- United States, 1999 : recommendations of the Advisory Committee on Immunization Practices (ACIP)

[PDF - 359.26 KB]

Personal Author:

Arguin, Paul M.

January 8, 1999 | MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control. 1999; 48(RR-1):1-21.

Description:

These revised recommendations of the Advisory Committee on Immunization Practices update the previous recommendations on rabies prevention (MMWR 1991;...

Status:

superseded

File Type:

[PDF - 359.26 KB]

File Type:

[PDF - 359.26 KB]
Human Rabies Prevention–United States, 2008: Recommendations of the Advisory Committee on Immunization Practices

[PDF - 547.77 KB]

Personal Author:

Briggs, Deborah ;

Brown, Catherine M.
...

May 23, 2008 | MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports ; v. 57, no. RR-3

Description:

These recommendations of the Advisory Committee on Immunization Practices (ACIP) update the previous recommendations on human rabies prevention (CDC. ...

Status:

current

File Type:

[PDF - 547.77 KB]

File Type:

[PDF - 547.77 KB]

Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies : recommendations of the advisory committee on immunization practices

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