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Antimicrobial treatment and prophylaxis of plague : recommendations for naturally acquired infections and bioterrorism response
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July 16 2021
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Source: MMWR Recommendations and Reports 70(3):1-27
[PDF-490.67 KB]
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Journal Article:Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports
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Corporate Authors:National Center for Emerging and Zoonotic Infectious Diseases (U.S.)Division of Vector-Borne Diseases. Bacterial Diseases Branch. ; Center on Birth Defects and Developmental Disabilities (Centers for Disease Control and Prevention). Division of Birth Defects and Infant Disorders. Research and Prevention Branch. Infant Outcomes Monitoring. ; National Center for Emerging and Zoonotic Infectious Diseases (U.S.)Division of Preparedness and Emerging Infections.
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Description:This report provides CDC recommendations to U.S. health care providers regarding treatment, pre-exposure prophylaxis, and postexposure prophylaxis of plague. Yersinia pestis, the bacterium that causes plague, leads to naturally occurring disease in the United States and other regions Worldwide and is recognized as a potential bioterrorism weapon. A bioweapon attack with Y. pestis could potentially infect thousands, requiring rapid and informed decision making by clinicians and public health agencies. The U.S. government stockpiles a variety of medical countermeasures to mitigate the effects of a bioterrorism attack (e.g., antimicrobials, antitoxins, and vaccines) for which the 21st Century Cures Act mandates the development of evidence-based guidelines on appropriate use. Guidelines for treatment and postexposure prophylaxis of plague were published in 2000 by a nongovernmental work group; since then, new human clinical data, animal study data, and U.S. Food and Drug Administration approvals of additional countermeasures have become available. To develop a comprehensive set of updated guidelines, CDC conducted a series of systematic literature reviews on human treatment of plague and other relevant topics to collect a broad evidence base for the recommendations in this report. Evidence from CDC reviews and additional sources were presented to subject matter experts during a series of forums. CDC considered individual expert input while developing these guidelines, which provide recommended best practices for treatment and prophylaxis of human plague for both naturally occurring disease and following a bioterrorism attack. The guidelines do not include information on diagnostic tTesting, triage decisions, or logistics involved in dispensing medical countermeasures. Clinicians and public health officials can use these guidelines to prepare their organizations, hospitals, and communities to respond to a plague mass-casualty event and as a guide for treating patients affected by plague.
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ISSN:1057-5987 (print);1545-8601 (digital);
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Pubmed ID:34264565
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Pubmed Central ID:PMC8312557
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Pages in Document:27 pdf pages
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Volume:70
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Issue:3
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