Dietary intake of soy and cruciferous vegetables and treatment-related symptoms in Chinese American and non-Hispanic White breast cancer survivors

Details

• Alternative Title:
  Breast Cancer Res Treat
• Personal Author:
  Nomura, Sarah J. O. ; Hwang, Yi-Ting ; Gomez, Scarlett Lin ; Fung, Teresa T. ; Yeh, Shu-Lan ; Dash, Chiranjeev ; Allen, Laura ; Philips, Serena ; Hilakivi-Clarke, Leena ; Zheng, Yun-Ling ; Wang, Judy Huei-yu
• Description:
  PURPOSE
  
  This project examined the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors.
  
  METHODS
  
  This cross-sectional study included 192 CA and 173 NHW female breast cancer survivors (stages 0–III, diagnosed between 2006–2012) recruited from two California cancer registries, who had completed primary treatment. Patient-reported data on treatment-related symptoms and potential covariates were collected via telephone interviews. Dietary data were ascertained by mailed questionnaires. The outcomes evaluated were menopausal symptoms (hot flashes, night sweats, vaginal dryness, vaginal discharge), joint problems, fatigue, hair thinning/loss and memory problems. Associations between soy and cruciferous vegetables and symptoms were assessed using logistic regression. Analyses were further stratified by race/ethnicity and endocrine therapy usage (non-user, tamoxifen, aromatase inhibitors).
  
  RESULTS
  
  Soy food and cruciferous vegetable intake ranged from no intake to 431 and 865 grams/day, respectively, and was higher in CA survivors. Higher soy food intake was associated with lower odds of menopausal symptoms (≥ 24.0 versus 0 grams/day, OR=0.51, 95% CI: 0.25, 1.03), and fatigue (≥ 24.0 versus 0 grams/day, OR=0.43, 95% CI: 0.22, 0.84). However, when stratified by race/ethnicity, associations were statistically significant in NHW survivors only. Compared with low intake, higher cruciferous vegetable intake was associated with lower odds of experiencing menopausal symptoms (≥70.8 versus <33.0 grams/day, OR=0.50, 95% CI: 0.25, 0.97) in the overall population.
  
  CONCLUSIONS
  
  In this population of breast cancer survivors, higher soy and cruciferous vegetable intake was associated with less treatment-related menopausal symptoms and fatigue.
  
  
• Subjects:
  Aged Antineoplastic Agents, Hormonal Aromatase Inhibitors Article Asian Breast Cancer Survivors Breast Neoplasms California Cancer Survivors Cross-Cultural Comparison Cross-Sectional Studies Cruciferous Vegetables Diet Surveys Endocrine Therapy Fatigue Female Hispanic Or Latino Humans Late Treatment Effects Menopause Middle Aged Soy Foods Vegetables White People

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• Source:
  Breast Cancer Res Treat. 168(2):467-479
• Pubmed ID:
  29230660
• Pubmed Central ID:
  PMC5928523
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; R21CA139408/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; K07 CA197112/CA/NCI NIH HHSUnited States/ ; P30 CA051008/CA/NCI NIH HHSUnited States/ ; R21 CA139408/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  168
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b4146e344e2ba0b85e032db2ff0976d01b5362cddee8cded490abe33d696b244
• Download URL:
  https://stacks.cdc.gov/view/cdc/70137/cdc_70137_DS1.pdf
• File Type:
  [PDF - 394.57 KB ]