Genetic Variation in Biotransformation Enzymes, Air Pollution Exposures, and Risk of Spina Bifida

Details

• Alternative Title:
  Am J Med Genet A
• Personal Author:
  Padula, Amy M. ; Yang, Wei ; Schultz, Kathleen ; Lurmann, Fred ; Hammond, S. Katharine ; Shaw, Gary M.
• Description:
  Spina bifida is a birth defect characterized by incomplete closure of the embryonic neural tube. Genetic factors as well as environmental factors have been observed to influence risks for spina bifida. Few studies have investigated possible gene-environment interactions that could contribute to spina bifida risk. The aim of this study is to examine the interaction between gene variants in biotransformation enzyme pathways and ambient air pollution exposures and risk of spina bifida. We evaluated the role of air pollution exposure during pregnancy and gene variants of biotransformation enzymes from bloodspots and buccal cells in a California population-based case-control (86 cases of spina bifida and 208 non-malformed controls) study. We considered race/ethnicity and folic acid vitamin use as potential effect modifiers and adjusted for those factors and smoking. We observed gene-environment interactions between each of the five pollutants and several gene variants: NO (ABCC2), NO| (ABCC2, SLC01B1), PM| (ABCC2, CYP1A1, CYP2B6, CYP2C19, CYP2D6, NAT2, SLC01B1, SLC01B3), PM| (CYP1A1 and CYP1A2). These analyses show positive interactions between air pollution exposure during early pregnancy and gene variants associated with metabolizing enzymes. These exploratory results suggest that some individuals based on their genetic background may be more susceptible to the adverse effects of pollution.
• Subjects:
  Air Pollution Article Congenital Anomalies Gene Gene-environment Spina Bifida
• Source:
  Am J Med Genet A. 176(5):1055-1090
• Pubmed ID:
  29681089
• Pubmed Central ID:
  PMC6320343
• Document Type:
  Journal Article
• Funding:
  P01 ES022849/ES/NIEHS NIH HHS/United States ; R00 ES021470/ES/NIEHS NIH HHS/United States ; T42 OH008429/OH/NIOSH CDC HHS/United States ; U50 DD925286/DD/NCBDD CDC HHS/United States
• Volume:
  176
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0e196098f8873b7e4350be8791edcadeacdb9524300a635de49274f34202d011
• Download URL:
  https://stacks.cdc.gov/view/cdc/61819/cdc_61819_DS1.pdf
• File Type:
  [PDF - 923.06 KB ]