Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant

Sridhar, Siddharth; Yip, Cyril C.Y.; Wu, Shusheng; Cai, Jianpiao; Zhang, Anna Jin-Xia; Leung, Kit-Hang; Chung, Tom W.H.; Chan, Jasper F.W.; Chan, Wan-Mui; Teng, Jade L.L.; Au-Yeung, Rex K.H.; Cheng, Vincent C.C.; Chen, Honglin; Lau, Susanna K.P.; Woo, Patrick C.Y.; Xia, Ning-Shao; Lo, Chung-Mau; Yuen, Kwok-Yung

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Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant

Supporting Files Public Domain

December 2018
By Sridhar, Siddharth ; Yip, Cyril C.Y. ; Wu, Shusheng ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Sridhar, Siddharth ; Yip, Cyril C.Y. ; Wu, Shusheng ; Cai, Jianpiao ; Zhang, Anna Jin-Xia ; Leung, Kit-Hang ; Chung, Tom W.H. ; Chan, Jasper F.W. ; Chan, Wan-Mui ; Teng, Jade L.L. ; Au-Yeung, Rex K.H. ; Cheng, Vincent C.C. ; Chen, Honglin ; Lau, Susanna K.P. ; Woo, Patrick C.Y. ; Xia, Ning-Shao ; Lo, Chung-Mau ; Yuen, Kwok-Yung
Description:

All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.
Subjects:

Chronic Hepatitis Hepatitis Hepatitis E Hev Immunocompromised Liver Transplant Rat Hepatitis E Virus Rat Hepatitis E Virus As Cause Of Persistent Hepatitis After Liver Transplant Research Rodents Viruses Zoonoses
Source:

Emerg Infect Dis. 24(12):2241-2250
Pubmed ID:

30457530
Pubmed Central ID:

PMC6256372
Document Type:

Journal Article
Place as Subject:

Hong Kong
Location:

Asia
Volume:

24
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:9ef91f6700046e433639e798b043aa612ac7e72ea1ea1c0e6a4142dbcd797181
Download URL:

https://stacks.cdc.gov/view/cdc/61358/cdc_61358_DS1.pdf
File Type:

[PDF - 3.36 MB ]

File Language:

English

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