Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Dutta, Anupriya ; Uno, Hajime ; Lorenz, David R. ; Wolinsky, Steven M. ; Gabuzda, Dana
• Description:
  Immunological parameters that influence susceptibility to virus-associated cancers in HIV-seronegative individuals are unclear. We conducted a case-control cohort study of immunological parameters associated with development of incident virus-associated cancers among 532 HIV-seronegative men who have sex with men (MSM) enrolled in the Multicenter AIDS Cohort Study (MACS) with median (IQR) 21 (8-26) years of follow-up. Thirty-two incident virus-associated cancers (anal cancer, non-Hodgkin lymphoma, liver cancer, other cancers with etiologies linked to human papillomavirus, Epstein-Barr virus, hepatitis B virus, or human herpesvirus-8) were identified among 3,408 HIV-seronegative men in the MACS during 1984-2010. Cases were matched for demographics, smoking, and follow-up to 500 controls without cancer. Mixed-effects and Cox regression models were used to examine associations between nadir or recent CD4, CD8, and white blood cell (WBC) counts or CD4:CD8 ratios and subsequent diagnosis of virus-associated cancers. Men with incident virus-associated cancers had lower CD4 and WBC counts over a 6-year window prior to diagnosis compared to men without cancer (p = 0.001 and 0.03, respectively). Low CD4 cell count and nadir, CD4 count-nadir differential, and CD4:CD8 ratio nadir were associated with increased 2-year risk of incident virus-associated cancers in models adjusted for demographics and smoking (hazard ratios 1.2-1.3 per 100 or 0.1 unit decrease, respectively; p < 0.01). Other associated factors included heavy smoking and past or current hepatitis B virus infection. These findings show that low CD4 cell counts, CD4 nadir, and CD4:CD8 cell ratios are independent predictors for subsequent risk of virus-associated cancers in HIV-seronegative MSM.
• Subjects:
  Adult Case-Control Studies CD4-CD8 Ratio HIV Seronegativity Homosexuality, Male Humans Leukocyte Count Longitudinal Studies Male Middle Aged Neoplasms Smoking T-Lymphocyte Subsets

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• Keywords:
  Cancer Risk CD4 T Cells CD8 T Cells HBV Lymphopenia Oncogenic Viruses
• Source:
  Cancer Causes Control. 29(11):1131-1142
• Pubmed ID:
  30315476
• Pubmed Central ID:
  PMC6245112
• Document Type:
  Journal Article
• Funding:
  U01 AI035042/AI/NIAID NIH HHSUnited States/ ; DA028994/DA/NIDA NIH HHSUnited States/ ; T32 AI007386/AI/NIAID NIH HHSUnited States/ ; DA30985/DA/NIDA NIH HHSUnited States/ ; T32 CA070083/CA/NCI NIH HHSUnited States/ ; U01 AI035041/AI/NIAID NIH HHSUnited States/ ; UM1 AI035043/AI/NIAID NIH HHSUnited States/ ; U58 DP000795/DP/NCCDPHP CDC HHSUnited States/ ; R01 DA030985/DA/NIDA NIH HHSUnited States/ ; DP1 DA028994/DA/NIDA NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; U01 AI035040/AI/NIAID NIH HHSUnited States/ ; U01 AI035039/AI/NIAID NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; DA40391/DA/NIDA NIH HHSUnited States/ ; T32 AG000222/AG/NIA NIH HHSUnited States/ ; TR000424/TR/NCATS NIH HHSUnited States/ ; UL1 TR000424/TR/NCATS NIH HHSUnited States/ ; AG000222/AG/NIA NIH HHSUnited States/ ; HHSN261201000035C/PC/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U01 AI035043/AI/NIAID NIH HHSUnited States/ ; R01 DA040391/DA/NIDA NIH HHSUnited States/ ; UL1 TR001102/TR/NCATS NIH HHSUnited States/ ; TR001102/TR/NCATS NIH HHSUnited States/ ; UL1 TR003098/TR/NCATS NIH HHSUnited States/
• Volume:
  29
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e6ffff09e8e4d69310e1949eae785c11b936cdad9b0cfc5b6a6608814fc3105f
• Download URL:
  https://stacks.cdc.gov/view/cdc/61223/cdc_61223_DS1.pdf
• File Type:
  [PDF - 1.12 MB ]