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Dietary Patterns, Bone Lead and Incident Coronary Heart Disease among Middle-aged to Elderly Men
  • Published Date:
    Sep 27 2018
  • Source:
    Environ Res. 168:222-229.
  • Language:
    English


Public Access Version Available on: January 01, 2020 information icon
Please check back on the date listed above.
Details:
  • Pubmed ID:
    30317107
  • Pubmed Central ID:
    PMC6263823
  • Description:
    Background:

    Most absorbed lead ends up in the bone, where it can be measured as a biomarker of cumulative exposure, elevations of which have been shown to predict a higher risk of coronary heart disease (CHD). Knowledge about the role of dietary patterns is critical to the development of effective interventions for the cardiovascular toxicity of cumulative lead exposure.

    Methods:

    594 men, free of CHD at baseline, were followed from August 1991 to June 2011 in the Normative Aging Study. Bone lead concentrations were measured by K-shell-X-ray fluorescence. Dietary patterns were identified using principal components analysis. Two dietary patterns were identified: a ‘prudent’ pattern characterized by high intake of fruit, vegetables, legumes, tomatoes, poultry, and seafood; and a ‘Western’ pattern, with high intake of red meat, processed meat, refined grains, high-fat dairy products, high-energy drinks, fries, butter and eggs. Cox proportional hazard models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CHD. Effect modification on the multiplicative scale was examined through cross-product interaction terms.

    Results:

    137 men developed incident CHD events during 5,071 person-years of follow-up. After adjusting for age, body mass index, total energy intake, smoking status, total cholesterol to high-density lipoprotein ratio, education and occupation, an HR of incident CHD was 1.64 (95% CI: 1.27–2.11) with each doubling in patella lead concentration in the low prudent diet group (
    Conclusions:

    Prudent diet may reduce the risk of development of CHD in relation to patella lead. However, these findings need to be interpreted with caution, given the modest sample size.

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