CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax infection in Ethiopia: A randomized controlled trial
-
May 16 2017
-
-
Source: PLoS Med. 14(5).
[PDF-2.03 MB]
Details:
-
Alternative Title:PLoS Med
-
Personal Author:
-
Description:Background
Recent efforts in malaria control have resulted in great gains in reducing the burden of Plasmodium falciparum, but P. vivax has been more refractory. Its ability to form dormant liver stages confounds control and elimination efforts. To compare the efficacy and safety of primaquine regimens for radical cure, we undertook a randomized controlled trial in Ethiopia.
Methods and findings
Patients with normal glucose-6-phosphate dehydrogenase status with symptomatic P. vivax mono-infection were enrolled and randomly assigned to receive either chloroquine (CQ) or artemether-lumefantrine (AL), alone or in combination with 14 d of semi-supervised primaquine (PQ) (3.5 mg/kg total). A total of 398 patients (n = 104 in the CQ arm, n = 100 in the AL arm, n = 102 in the CQ+PQ arm, and n = 92 in the AL+PQ arm) were followed for 1 y, and recurrent episodes were treated with the same treatment allocated at enrolment. The primary endpoints were the risk of P. vivax recurrence at day 28 and at day 42.
Conclusions
Despite evidence of CQ-resistant P. vivax, the risk of recurrence in this study was greater following treatment with AL unless it was combined with a supervised course of PQ. PQ combined with either CQ or AL was well tolerated and reduced recurrence of vivax malaria by 5-fold at 1 y.
Trial registration
ClinicalTrials.gov NCT01680406
Why was this study done?
What did the researchers do and find?
What do these findings mean?
-
Subjects:
-
Source:
-
Pubmed ID:28510573
-
Pubmed Central ID:PMC5433686
-
Document Type:
-
Place as Subject:
-
Volume:14
-
Issue:5
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
Supporting Files
-
docx 
doc 
pdf 
pdf 
pdf 
gif 
jpeg 
gif 
jpeg 
gif 
gif 
jpeg 
gif 
jpeg 
gif 
jpeg 
jpeg 
gif 
jpeg 
gif 
jpeg 
xml 
docx
