A Retrospective Review of Hospital-Based Data on Enteric Fever in India, 2014–2015

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Sur, Dipika ; Barkume, Caitlin ; Mukhopadhyay, Bratati ; Date, Kashmira ; Ganguly, Nirmal Kumar ; Garrett, Denise
• Description:
  Background
  
  Enteric fever remains a threat to many countries with minimal access to clean water and poor sanitation infrastructure. As part of a multisite surveillance study, we conducted a retrospective review of records in 5 hospitals across India to gather evidence on the burden of enteric fever.
  
  Methods
  
  We examined hospital records (laboratory and surgical registers) from 5 hospitals across India for laboratory-confirmed Salmonella Typhi or Salmonella Paratyphi cases and intestinal perforations from 2014–2015. Clinical data were obtained where available. For laboratory-confirmed infections, we compared differences in disease burden, age, sex, clinical presentation, and antimicrobial resistance.
  
  Results
  
  Of 267536 blood cultures, 1418 (0.53%) were positive for S. Typhi or S. Paratyphi. Clinical data were available for 429 cases (72%); a higher proportion of participants with S. Typhi infection were hospitalized, compared with those with S. Paratyphi infection (44% vs 35%). We observed resistance to quinolones among 82% of isolates, with cases of cephalosporin resistance (1%) and macrolide resistance (9%) detected. Of 94 participants with intestinal perforations, 16 (17%) had a provisional, final, or laboratory-confirmed diagnosis of enteric fever.
  
  Discussion
  
  Data show a moderate burden of enteric fever in India. Enteric fever data should be systematically collected to facilitate evidence-based decision-making by countries for typhoid conjugate vaccines.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Anti-Bacterial Agents Child Child, Preschool Cross-Sectional Studies Drug Resistance, Bacterial Female Hospitals Humans Infant Male Middle Aged Retrospective Studies Salmonella Paratyphi A Salmonella Typhi Time Factors Typhoid-Paratyphoid Vaccines Typhoid Fever Young Adult

  More +
• Source:
  J Infect Dis. 2018; 218(Suppl 4):S206-S213.
• Pubmed ID:
  30307566
• Pubmed Central ID:
  PMC6226629
• Document Type:
  Journal Article
• Place as Subject:
  India
• Volume:
  218
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3897dd5fc4133db346b19071c5d39b56c9b0f49ee50a4bc844f22392f332fcdb
• Download URL:
  https://stacks.cdc.gov/view/cdc/60736/cdc_60736_DS1.pdf
• File Type:
  [PDF - 198.26 KB ]