Poppers and PrEP: Use of Pre-Exposure Prophylaxis among Men Who Have Sex with Men Who Use Inhaled Nitrites

Details

• Alternative Title:
  AIDS Behav
• Personal Author:
  Hambrick, H. Rhodes ; Park, Su Hyun ; Schneider, John A. ; Mayer, Kenneth H. ; Carrico, Adam W. ; Sherman, Scott E. ; Duncan, Dustin T.
• Description:
  Men who have sex with men (MSM) commonly use inhaled nitrites, or poppers, though their use is a risk factor HIV seroconversion. Pre-exposure prophylaxis, or PrEP, is effective for HIV prevention, but is not widely used, and little is known regarding PrEP use and acceptability among MSM who use inhaled nitrites. We surveyed 580 MSM in Paris, France in 2016 about popper use, sexual behaviors including condomless anal intercourse (CAI), serosorting, and sexual positioning, PrEP use, PrEP candidacy, and interest in alternate PrEP delivery modalities. We included 444 HIV negative participants for the current study. 46.2% reported popper use in the prior 3 months. Using multivariate adjusted logistic regression, we found that popper users were more likely than non-users to consider themselves candidates for PrEP [adjusted relative risk ratio (aRRR) = 2.73; 95% CI 1.54-4.83], but they were not more likely to be current (aRRR = 1.54; 95% CI 0.71-3.33) or past (aRRR = 1.37; 95% CI 0.44-4.28) PrEP users. Mediation analyses indicated that increased CAI and serosorting partly explained the relationship between popper use and PrEP candidacy. There was considerable interest in alternate proposed PrEP delivery modalities, particularly long-acting injectable PrEP [adjusted risk ratio (aRR) = 1.43; 95% CI 1.15-1.79].
• Keywords:
  Adult Anti-HIV Agents France HIV Infections HIV Prevention HIV Serosorting Homosexuality, Male Humans Inhaled Nitrites Male Men Who Have Sex With Men Middle Aged Nitrites Odds Ratio Poppers Pre-Exposure Prophylaxis PrEP Sexual Behavior Surveys And Questionnaires Young Adult

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• Source:
  AIDS Behav. 22(11):3658-3672
• Pubmed ID:
  29744767
• Pubmed Central ID:
  PMC6226362
• Document Type:
  Journal Article
• Funding:
  U01PS005122/ACL HHSUnited States/ ; R01MH112406/National Institutes of Health/ ; U01PS005122/Centers for Disease Control and Prevention/ ; R01 MH112406/MH/NIMH NIH HHSUnited States/ ; R03DA039748/National Institutes of Health/ ; R03 DA039748/DA/NIDA NIH HHSUnited States/ ; R21 MH110190/MH/NIMH NIH HHSUnited States/ ; U01 PS005122/PS/NCHHSTP CDC HHSUnited States/ ; R21MH110190/National Institutes of Health/
• Volume:
  22
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eb3b5f0884cc846a63b8636358fea53ce8c356fecb6977a028f9e579c22ca99c
• Download URL:
  https://stacks.cdc.gov/view/cdc/60468/cdc_60468_DS1.pdf
• File Type:
  [PDF - 395.69 KB ]