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Distribution of behavioral patterns prior to infection among San Francisco men who have sex with men newly infected with HIV in 2014
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8 15 2017
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Source: J Acquir Immune Defic Syndr. 75(5):528-534
[PDF-322.77 KB]
Details:
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Alternative Title:J Acquir Immune Defic Syndr
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Personal Author:
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Description:Background
Despite continued reductions in the number of HIV cases reported among San Francisco men who have sex with men (MSM) and the HIV-prevention potential offered by pharmaceutical tools such as pre-exposure prophylaxis (PrEP), there are uncertainties, particularly given reported decreases in consistent condom use. A key uncertainty is what groups of MSM should be targeted. The present study estimates the distribution of behavioral patterns prior to infection among San Francisco MSM newly infected with HIV in 2014.
Methods
We used a novel modeling approach. The approach uses estimates from the National HIV Behavioral Surveillance System for MSM, the Medical Monitoring Project, two trials of PrEP, and a meta-analysis of per-act risks of HIV infection.
Results
The modeling study suggests that 76% of newly HIV-infected MSM in 2014 were individuals with no discernible strategy in the 6 months prior to infection: that is, they had condomless receptive anal intercourse with one or more partner not perceived to be HIV-uninfected. An estimated 7% of newly infected MSM were serosorters prior to infection.
Conclusions
Prevention efforts in San Francisco must reach HIV-uninfected MSM with no discernible behavioral strategy, a group that constitutes 8% of HIV-uninfected MSM in the city. Our study suggests that if all HIV-uninfected, San Francisco MSM with no discernible strategy had been on PrEP in 2014, there would have been 70% fewer HIV infections among San Francisco MSM. Uncertainty analysis suggests that PrEP's impact may be maximized by encouraging PrEP persistence and concomitant reductions in sexual risk behaviors.
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Pubmed ID:28481784
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Pubmed Central ID:PMC5649625
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Volume:75
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Issue:5
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