Long-Term Liver Disease, Treatment, and Mortality Outcomes Among 17,000 Persons Diagnosed with Chronic Hepatitis C Virus Infection: Current Chronic Hepatitis Cohort Study Status and Review of Findings

Details

• Alternative Title:
  Infect Dis Clin North Am
• Personal Author:
  Moorman, Anne C. ; Rupp, Loralee B. ; Gordon, Stuart C. ; Zhong, Yuna ; Xing, Jian ; Lu, Mei ; Boscarino, Joseph A. ; Schmidt, Mark A. ; Daida, Yihe G. ; Teshale, Eyasu H. ; Spradling, Philip R. ; Holmberg, Scott D.
• Corporate Authors:
  for the CHeCS Investigators
• Description:
  Chronic Hepatitis Cohort Study (CHeCS) publications using data from "real-world" patients with hepatitis C virus (HCV) have described demographic disparities in access to care; rates of advanced liver disease, morbidity, and mortality (2.5%-3.5% per year during 2006-10, although only 19% of all CHeCS decedents, and just 30% of those with deaths attributed to liver disease, had HCV listed on death certificate); substantial comorbidities, such as diabetes, advanced liver fibrosis (29% prevalence), renal disease, and depression, and partial reversal of all these with successful antiviral therapy; patient risk behaviors; and use of noninvasive markers to assess liver disease.
• Subjects:
  Adult Aged Antiviral Agents Cohort Studies Female Hepacivirus Hepatitis C, Chronic Humans Liver Cirrhosis Male Middle Aged Observational Studies As Topic Patient Reported Outcome Measures Ribavirin Time Factors Young Adult

  More +
• Keywords:
  Cirrhosis Comorbidities Direct-acting Antiviral Hepatitis C Mortality Real-world Cohort Sustained Viral Response
• Source:
  Infect Dis Clin North Am. 32(2):253-268
• Pubmed ID:
  29778254
• Pubmed Central ID:
  PMC6211170
• Document Type:
  Journal Article
• Funding:
  U18 PS005154/PS/NCHHSTP CDC HHSUnited States/ ; U18PS005154/ACL HHSUnited States/
• Volume:
  32
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f602f552d7e2b035b71d720d2924b3e1012c9b6dcf1ceb9a8c4d941ceb0d0cef
• Download URL:
  https://stacks.cdc.gov/view/cdc/60207/cdc_60207_DS1.pdf
• File Type:
  [PDF - 115.97 KB ]