Details:

Alternative Title:
PLoS One
Personal Author:
Lee, Duk-Hee ; Steffes, Michael W. ; Sjödin, Andreas ; Jones, Richard S. ; Needham, Larry L. ; ... More +
Lee, Duk-Hee ; Steffes, Michael W. ; Sjödin, Andreas ; Jones, Richard S. ; Needham, Larry L. ; Jacobs, David R. Less -
Description:
Background

There is emerging evidence that background exposure to persistent organic pollutants (POPs) are important in the development of conditions predisposing to diabetes as well as of type 2 diabetes itself. We recently reported that low dose POPs predicted incident type 2 diabetes in a nested case-control study. The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study.

Methodology/Principal Findings

The 90 controls were diabetes-free during 20 years follow-up. They were a stratified random sample, enriched with overweight and obese persons. POPs measured in 1987-88 (year 2) sera included 8 organochlorine (OC) pesticides, 22 polychlorinated biphenyls (PCBs), and 1 polybrominated biphenyl (PBB). Body mass index (BMI), triglycerides, HDL-cholesterol, LDL-cholesterol, and homeostasis model assessment value for insulin resistance (HOMA–IR) were study outcomes at 2005-06 (year 20). The evolution of study outcomes during 18 years by categories of serum concentrations of POPs at year 2 was evaluated by adjusting for the baseline values of outcomes plus potential confounders. Parallel to prediction of type 2 diabetes, many statistically significant associations of POPs with dysmetabolic conditions appeared at low dose, forming inverted U-shaped dose-response relations. Among OC pesticides, p,p'-DDE most consistently predicted higher BMI, triglycerides, and HOMA-IR and lower HDL-cholesterol at year 20 after adjusting for baseline values. Oxychlordane, trans-nonachlor, and hexachlorobenzene also significantly predicted higher triglycerides. Persistent PCBs with ≥7 chlorides predicted higher BMI, triglycerides, and HOMA-IR and lower HDL-cholesterol at year 20 with similar dose-response curves.

Conclusions/Significance

Simultaneous exposure to various POPs in the general population may contribute to development of obesity, dyslipidemia, and insulin resistance, common precursors of type 2 diabetes and cardiovascular diseases. Although obesity is a primary cause of these metabolic abnormalities, POPs exposure may contribute to excess adiposity and other features of dysmetabolism.


Subjects:
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Adult Case-Control Studies Diabetes Mellitus, Type 2 Dyslipidemias Environmental Exposure Environmental Pollutants Female Humans Hydrocarbons, Chlorinated Insulin Resistance Male Obesity Pesticides Polychlorinated Biphenyls Risk Factors Young Adult
Source:
PLoS One. 2011; 6(1).
Pubmed ID:
21298090
Pubmed Central ID:
PMC3027626
Document Type:
Journal Article
Funding:
R01 HL053560/HL/NHLBI NIH HHS/United States ; N01-HC-48047/HC/NHLBI NIH HHS/United States ; N01HC48049/HL/NHLBI NIH HHS/United States ; R01-HL-53560/HL/NHLBI NIH HHS/United States ; N01-HC-95095/HC/NHLBI NIH HHS/United States ; ... More +
R01 HL053560/HL/NHLBI NIH HHS/United States ; N01-HC-48047/HC/NHLBI NIH HHS/United States ; N01HC48049/HL/NHLBI NIH HHS/United States ; R01-HL-53560/HL/NHLBI NIH HHS/United States ; N01-HC-95095/HC/NHLBI NIH HHS/United States ; N01-HC-48050/HC/NHLBI NIH HHS/United States ; N01HC95095/HL/NHLBI NIH HHS/United States ; N01-HC-48049/HC/NHLBI NIH HHS/United States ; N01HC48050/HL/NHLBI NIH HHS/United States ; N01HC48047/HL/NHLBI NIH HHS/United States ; N01-HC-48048/HC/NHLBI NIH HHS/United States ; N01HC48048/HL/NHLBI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5dd91a7def624d3d73f81fd17992a374fd81ea42ca26adcb1027af5cb7e71bcc
Download URL:
https://stacks.cdc.gov/view/cdc/60072/cdc_60072_DS1.pdf
File Type:

Supporting Files

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