Details:

Alternative Title:
PLoS One
Personal Author:
Lee, Duk-Hee ; Steffes, Michael W. ; Sjödin, Andreas ; Jones, Richard S. ; Needham, Larry L. ; ... More +
Lee, Duk-Hee ; Steffes, Michael W. ; Sjödin, Andreas ; Jones, Richard S. ; Needham, Larry L. ; Jacobs, David R. Less -
Description:
Background

There is emerging evidence that background exposure to persistent organic pollutants (POPs) are important in the development of conditions predisposing to diabetes as well as of type 2 diabetes itself. We recently reported that low dose POPs predicted incident type 2 diabetes in a nested case-control study. The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study.

Methodology/Principal Findings

The 90 controls were diabetes-free during 20 years follow-up. They were a stratified random sample, enriched with overweight and obese persons. POPs measured in 1987-88 (year 2) sera included 8 organochlorine (OC) pesticides, 22 polychlorinated biphenyls (PCBs), and 1 polybrominated biphenyl (PBB). Body mass index (BMI), triglycerides, HDL-cholesterol, LDL-cholesterol, and homeostasis model assessment value for insulin resistance (HOMA–IR) were study outcomes at 2005-06 (year 20). The evolution of study outcomes during 18 years by categories of serum concentrations of POPs at year 2 was evaluated by adjusting for the baseline values of outcomes plus potential confounders. Parallel to prediction of type 2 diabetes, many statistically significant associations of POPs with dysmetabolic conditions appeared at low dose, forming inverted U-shaped dose-response relations. Among OC pesticides, p,p'-DDE most consistently predicted higher BMI, triglycerides, and HOMA-IR and lower HDL-cholesterol at year 20 after adjusting for baseline values. Oxychlordane, trans-nonachlor, and hexachlorobenzene also significantly predicted higher triglycerides. Persistent PCBs with ≥7 chlorides predicted higher BMI, triglycerides, and HOMA-IR and lower HDL-cholesterol at year 20 with similar dose-response curves.

Conclusions/Significance

Simultaneous exposure to various POPs in the general population may contribute to development of obesity, dyslipidemia, and insulin resistance, common precursors of type 2 diabetes and cardiovascular diseases. Although obesity is a primary cause of these metabolic abnormalities, POPs exposure may contribute to excess adiposity and other features of dysmetabolism.


Subject:
[+]
Adult
Case-Control Studies
Diabetes Mellitus, Type 2
Dyslipidemias
Environmental Exposure
Environmental Pollutants
Female
Humans
Hydrocarbons, Chlorinated
Insulin Resistance
Male
Obesity
Pesticides
Polychlorinated Biphenyls
Risk Factors
Young Adult

Source:
PLoS One. 2011; 6(1).
Pubmed ID:
21298090
Pubmed Central ID:
PMC3027626
Document Type:
Journal Article
Funding:
R01 HL053560/HL/NHLBI NIH HHS/United States ; N01-HC-48047/HC/NHLBI NIH HHS/United States ; N01HC48049/HL/NHLBI NIH HHS/United States ; R01-HL-53560/HL/NHLBI NIH HHS/United States ; N01-HC-95095/HC/NHLBI NIH HHS/United States ; ... More +
R01 HL053560/HL/NHLBI NIH HHS/United States ; N01-HC-48047/HC/NHLBI NIH HHS/United States ; N01HC48049/HL/NHLBI NIH HHS/United States ; R01-HL-53560/HL/NHLBI NIH HHS/United States ; N01-HC-95095/HC/NHLBI NIH HHS/United States ; N01-HC-48050/HC/NHLBI NIH HHS/United States ; N01HC95095/HL/NHLBI NIH HHS/United States ; N01-HC-48049/HC/NHLBI NIH HHS/United States ; N01HC48050/HL/NHLBI NIH HHS/United States ; N01HC48047/HL/NHLBI NIH HHS/United States ; N01-HC-48048/HC/NHLBI NIH HHS/United States ; N01HC48048/HL/NHLBI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5dd91a7def624d3d73f81fd17992a374fd81ea42ca26adcb1027af5cb7e71bcc
File Type:

Supporting Files

• 	pone.0015977.s004.docx	docx
  	pone.0015977.s005.docx	docx
  	pone.0015977.t001.gif	gif
  	pone.0015977.t001.jpg	jpeg
  	pone.0015977.t002.gif	gif
  	pone.0015977.t002.jpg	jpeg
  	pone.0015977.t003.gif	gif
  	pone.0015977.t003.jpg	jpeg
  	pone.0015977.t004.gif	gif
  	pone.0015977.t004.jpg	jpeg
  	pone.0015977.g001.gif	gif
  	pone.0015977.t005.gif	gif
  	pone.0015977.t005.jpg	jpeg
  	pone.0015977.g001.jpg	jpeg
  	pone.0015977.g002.gif	gif
  	pone.0015977.g002.jpg	jpeg
  	pone.0015977.nxml	xml
  	pone.0015977.s001.pdf	pdf
  	pone.0015977.s002.pdf	pdf
  	pone.0015977.s003.docx	docx

More +