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H pylori-associated pathologic findings among Alaska native patients
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Dec 2018
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Source: Int J Circumpolar Health 2018; 77(1)
[PDF-920.73 KB]
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Alternative Title:Int J Circumpolar Health
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Description:Helicobacter pylori infection is common among Alaska native (AN) people, however scant gastric histopathologic data is available for this population This study aimed to characterize gastric histopathology and H pylori infection among AN people We enrolled AN adults undergoing upper endoscopy Gastric biopsy samples were evaluated for pathologic changes, the presence of H pylori, and the presence of cag pathogenicity island-positive bacteria Of 432 persons; two persons were diagnosed with gastric adenocarcinoma, two with MALT lymphoma, 40 (10%) with ulcers, and 51 (12%) with intestinal metaplasia Fifty-five per cent of H pylori-positive persons had cag pathogenicity island positive bacteria The gastric antrum had the highest prevalence of acute and chronic moderate-severe gastritis H pylori-positive persons were 16 and four times more likely to have moderate-severe acute gastritis and chronic gastritis (p < 001), respectively An intact cag pathogenicity island positive was correlated with moderate-severe acute antral gastritis (53% vs 31%, p = 00003) H pylori-positive persons were more likely to have moderate-severe acute and chronic gastritis compared to H pylori-negative persons Gastritis and intestinal metaplasia were most frequently found in the gastric antrum Intact cag pathogenicity island positive was correlated with acute antral gastritis and intestinal metaplasia
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Pubmed ID:30157723
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Pubmed Central ID:PMC6116699
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Volume:77
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Issue:1
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