H pylori-associated pathologic findings among Alaska native patients

Details

• Alternative Title:
  Int J Circumpolar Health
• Personal Author:
  Nolen, Leisha Diane ; Bruden, Dana ; Miernyk, Karen ; McMahon, Brian J ; Sacco, Frank ; Varner, Wayne ; Mezzetti, Tom ; Hurlburt, Debby ; Tiesinga, James ; Bruce, Michael G
• Description:
  Helicobacter pylori infection is common among Alaska native (AN) people, however scant gastric histopathologic data is available for this population This study aimed to characterize gastric histopathology and H pylori infection among AN people We enrolled AN adults undergoing upper endoscopy Gastric biopsy samples were evaluated for pathologic changes, the presence of H pylori, and the presence of cag pathogenicity island-positive bacteria Of 432 persons; two persons were diagnosed with gastric adenocarcinoma, two with MALT lymphoma, 40 (10%) with ulcers, and 51 (12%) with intestinal metaplasia Fifty-five per cent of H pylori-positive persons had cag pathogenicity island positive bacteria The gastric antrum had the highest prevalence of acute and chronic moderate-severe gastritis H pylori-positive persons were 16 and four times more likely to have moderate-severe acute gastritis and chronic gastritis (p < 001), respectively An intact cag pathogenicity island positive was correlated with moderate-severe acute antral gastritis (53% vs 31%, p = 00003) H pylori-positive persons were more likely to have moderate-severe acute and chronic gastritis compared to H pylori-negative persons Gastritis and intestinal metaplasia were most frequently found in the gastric antrum Intact cag pathogenicity island positive was correlated with acute antral gastritis and intestinal metaplasia
• Subjects:
  Acute Disease Adolescent Adult Age Aged Alaska Natives Alcohol Drinking/ethnology Bacterial Proteins Biopsy Chronic Disease Female Gastritis Gastroscopy Helicobacter Pylori Humans Male Middle Aged Severity Of Illness Index Smoking / Ethnology Stomach Diseases Young Adult

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• Source:
  Int J Circumpolar Health 2018; 77(1)
• Pubmed ID:
  30157723
• Pubmed Central ID:
  PMC6116699
• Document Type:
  Journal Article
• Place as Subject:
  Alaska ; Arctic Regions
• Location:
  Alaska ; Arctic Regions
• Volume:
  77
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:168bbea6601648dbbd6f234241fd56234f50631bb999936c8396d9d77a7e45ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/59657/cdc_59657_DS1.pdf
• File Type:
  [PDF - 920.73 KB ]