Details:

Alternative Title:
Int J Circumpolar Health
Publisher's site:
http://dx.doi.org/10.1080/22423982.2018.1510715
Personal Author:
Nolen, Leisha Diane ; Bruden, Dana ; Miernyk, Karen ; McMahon, Brian J. ; Sacco, Frank ; ... More +
Nolen, Leisha Diane ; Bruden, Dana ; Miernyk, Karen ; McMahon, Brian J. ; Sacco, Frank ; Varner, Wayne ; Mezzetti, Tom ; Hurlburt, Debby ; Tiesinga, James ; Bruce, Michael G. Less -
Description:
Helicobacter pylori infection is common among Alaska native (AN) people, however scant gastric histopathologic data is available for this population. This study aimed to characterise gastric histopathology and H. pylori infection among AN people. We enrolled AN adults undergoing upper endoscopy. Gastric biopsy samples were evaluated for pathologic changes, the presence of H. pylori, and the presence of cag pathogenicity island-positive bacteria. Of 432 persons; two persons were diagnosed with gastric adenocarcinoma, two with MALT lymphoma, 40 (10%) with ulcers, and 51 (12%) with intestinal metaplasia. Fifty-five per cent of H. pylori-positive persons had cag pathogenicity island positive bacteria. The gastric antrum had the highest prevalence of acute and chronic moderate-severe gastritis. H. pylori-positive persons were 16 and four times more likely to have moderate-severe acute gastritis and chronic gastritis (p < 0.01), respectively. An intact cag pathogenicity island positive was correlated with moderate-severe acute antral gastritis (53% vs. 31%, p = 0.0003). H. pylori-positive persons were more likely to have moderate-severe acute and chronic gastritis compared to H. pylori-negative persons. Gastritis and intestinal metaplasia were most frequently found in the gastric antrum. Intact cag pathogenicity island positive was correlated with acute antral gastritis and intestinal metaplasia.
Subject:
[+]
Acute Disease
Adolescent
Adult
Aged
Aged, 80 And Over
Alaskan Natives
Alcohol Drinking/ethnology
Bacterial Proteins
Biopsy
Chronic Disease
Female
Gastritis
Gastroscopy
Helicobacter Pylori
Humans
Male
Middle Aged
Severity Of Illness Index
Smoking / Ethnology
Stomach Diseases
Young Adult

Source:
Int J Circumpolar Health. 2018; 77(1).
Pubmed ID:
30157723
Pubmed Central ID:
PMC6116699
Document Type:
Journal Article
Place as Subject:
Alaska ; Arctic Regions
Alaska ; Arctic Regions Less -
Collection(s):
CDC Public Access
Arctic Investigations Program
Main Document Checksum:
[+]
urn:sha256:168bbea6601648dbbd6f234241fd56234f50631bb999936c8396d9d77a7e45ae
File Type:

Supporting Files

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  	ZICH_A_1510715_F0001_B.gif	gif
  	ZICH_A_1510715_F0001_B.jpg	jpeg

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