Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding
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Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding

Filetype[PDF-573.50 KB]


  • English

  • Details:

    • Alternative Title:
      Influenza Other Respir Viruses
    • Description:
      Background

      The prevalence, symptom course, and shedding in persons infected with the 4 most common human coronaviruses (HCoV)‐229E, HKU1, NL63, and OC43 are poorly described.

      Objectives

      We estimate their prevalence and associated symptoms among college students identified via a social network study design.

      Patients/Methods

      We collected 1‐3 samples (n = 250 specimens) from 176 participants between October 2012 and January 17, 2013: participants with acute respiratory infection (ARI; cough and body aches or chills or fever/feverishness) and their social contacts. Virus was detected using RT‐PCR.

      Results

      30.4% (76/250) of specimens tested positive for any virus tested, and 4.8% (12/250) were positive for 2 or more viruses. Human coronaviruses (HCoVs [22.0%; 55/250]), rhinovirus (7.6%; 19/250), and influenza A (6.4%; 16/250) were most prevalent. Symptoms changed significantly over time among ARI participants with HCoV: the prevalence of cough and chills decreased over 6 days (P = .04, and P = .01, respectively), while runny nose increased over the same period (P = .02). HCoV‐NL63 was the most frequent virus detected 6 days following symptom onset (8.9%), followed by rhinovirus (6.7%).

      Conclusions

      During a 3‐month period covering a single season, HCoVs were common, even among social contacts without respiratory symptoms; specific symptoms may change over the course of HCoV‐associated illness and were similar to symptoms from influenza and rhinovirus.

    • Pubmed ID:
      29660826
    • Pubmed Central ID:
      PMC6086849
    • Document Type:
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