Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  Davis, Brian M. ; Foxman, Betsy ; Monto, Arnold S. ; Baric, Ralph S. ; Martin, Emily T. ; Uzicanin, Amra ; Rainey, Jeanette J. ; Aiello, Allison E.
• Description:
  Background ; The prevalence, symptom course, and shedding in persons infected with the 4 most common human coronaviruses (HCoV)‐229E, HKU1, NL63, and OC43 are poorly described. ; Objectives ; We estimate their prevalence and associated symptoms among college students identified via a social network study design. ; Patients/Methods ; We collected 1‐3 samples (n = 250 specimens) from 176 participants between October 2012 and January 17, 2013: participants with acute respiratory infection (ARI; cough and body aches or chills or fever/feverishness) and their social contacts. Virus was detected using RT‐PCR. ; Results ; 30.4% (76/250) of specimens tested positive for any virus tested, and 4.8% (12/250) were positive for 2 or more viruses. Human coronaviruses (HCoVs 22.0%; 55/250), rhinovirus (7.6%; 19/250), and influenza A (6.4%; 16/250) were most prevalent. Symptoms changed significantly over time among ARI participants with HCoV: the prevalence of cough and chills decreased over 6 days (P = .04, and P = .01, respectively), while runny nose increased over the same period (P = .02). HCoV‐NL63 was the most frequent virus detected 6 days following symptom onset (8.9%), followed by rhinovirus (6.7%). ; Conclusions ; During a 3‐month period covering a single season, HCoVs were common, even among social contacts without respiratory symptoms; specific symptoms may change over the course of HCoV‐associated illness and were similar to symptoms from influenza and rhinovirus.
• Subjects:
  • Female
  • Humans
  • Male
  • Prevalence
  • Respiratory Tract Infections
  • Students
  • Surveys and Questionnaires
  • Universities
  • Virus Diseases
  • Viruses
  More +
• Source:
  Influenza Other Respir Viruses. 12(5):582-590.
• Pubmed ID:
  29660826
• Pubmed Central ID:
  PMC6086849
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/59496/cdc_59496_DS1.pdf
• File Type:
  [PDF - 573.50 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7030c1c55b17265822c440b57b9483da1c4c923f2c671959eae0911e3f73d482