Transmission Dynamics of Highly Pathogenic Avian Influenza Virus A(H5Nx) Clade 2.3.4.4, North America, 2014–2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lee, Dong-Hun ; Torchetti, Mia Kim ; Hicks, Joseph ; Killian, Mary Lea ; Bahl, Justin ; Pantin-Jackwood, Mary ; Swayne, David E.
• Description:
  Eurasia highly pathogenic avian influenza virus (HPAIV) H5 clade 2.3.4.4 emerged in North America at the end of 2014 and caused outbreaks affecting >50 million poultry in the United States before eradication in June 2015. We investigated the underlying ecologic and epidemiologic processes associated with this viral spread by performing a comparative genomic study using 268 full-length genome sequences and data from outbreak investigations. Reassortant HPAIV H5N2 circulated in wild birds along the Pacific flyway before several spillover events transmitting the virus to poultry farms. Our analysis suggests that >3 separate introductions of HPAIV H5N2 into Midwest states occurred during March-June 2015; transmission to Midwest poultry farms from Pacific wild birds occurred ≈1.7-2.4 months before detection. Once established in poultry, the virus rapidly spread between Europe and chicken farms in neighboring states. Enhanced biosecurity is required to prevent the introduction and dissemination of HPAIV across the poultry industry.
• Subjects:
  Animals Bayes Theorem Disease Outbreaks Genome, Viral History, 21st Century Influenza A Virus Influenza In Birds Phylogeny Poultry Poultry Diseases/ Reassortant Viruses Research RNA, Viral

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• Source:
  Emerg Infect Dis. 24(10):1840-1848.
• Pubmed ID:
  30226167
• Pubmed Central ID:
  PMC6154162
• Document Type:
  Journal Article
• Place as Subject:
  Canada ; North America ; United States
• Location:
  North America
• Volume:
  24
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:018a2cf29d1f5be411e2691d78925261fa9572214b07e95531a1919149318d60
• Download URL:
  https://stacks.cdc.gov/view/cdc/59449/cdc_59449_DS1.pdf
• File Type:
  [PDF - 2.12 MB ]