The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum

Details

• Alternative Title:
  Nat Genet
• Personal Author:
  Neafsey, Daniel E. ; Galinsky, Kevin ; Jiang, Rays H. Y. ; Young, Lauren ; Sykes, Sean M. ; Saif, Sakina ; Gujja, Sharvari ; Goldberg, Jonathan M. ; Young, Sarah ; Zeng, Qiandong ; Chapman, Sinéad B. ; Dash, Aditya P. ; Anvikar, Anupkumar R. ; Sutton, Patrick L. ; Birren, Bruce W. ; Escalante, Ananias A. ; Barnwell, John W. ; Carlton, Jane M.
• Description:
  We sequenced and annotated the genomes of four P. vivax strains collected from disparate geographic locations, tripling the number of genome sequences available for this understudied parasite and providing the first genome-wide perspective of global variability in this species. We observe approximately twice as much SNP diversity among these isolates as we do among a comparable collection of isolates of P. falciparum, a malaria-causing parasite that results in higher mortality. This indicates a distinct history of global colonization and/or a more stable demographic history for P. vivax relative to P. falciparum, which is thought to have undergone a recent population bottleneck. The SNP diversity, as well as additional microsatellite and gene family variability, suggests a capacity for greater functional variation in the global population of P. vivax. These findings warrant a deeper survey of variation in P. vivax to equip disease interventions targeting the distinctive biology of this neglected but major pathogen.
• Subjects:
  Animals Genetic Variation Geography Humans Malaria, Falciparum Malaria, Vivax Microsatellite Repeats Molecular Sequence Data Phylogeny Plasmodium Falciparum Plasmodium Vivax Polymorphism, Single Nucleotide

  More +
• Source:
  Nat Genet. 44(9):1046-1050.
• Pubmed ID:
  22863733
• Pubmed Central ID:
  PMC3432710
• Document Type:
  Journal Article
• Funding:
  U19 AI089676/AI/NIAID NIH HHS/United States ; HHSN272200900018C/AI/NIAID NIH HHS/United States ; HHSN272200900008C/AI/NIAID NIH HHS/United States ; U19AI089676/AI/NIAID NIH HHS/United States ; HHSN272200900001C/AI/NIAID NIH HHS/United States ; R01GM084320/GM/NIGMS NIH HHS/United States ; HHSN266200400001C/AO/NIAID NIH HHS/United States ; R01 GM084320/GM/NIGMS NIH HHS/United States ; R01 GM080586/GM/NIGMS NIH HHS/United States
• Place as Subject:
  Africa ; Americas ; Asia
• Volume:
  44
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:23e48eb65742c94ad867e0bceac12421a3c7474cbc340274a2c9187d50b21a98
• Download URL:
  https://stacks.cdc.gov/view/cdc/59268/cdc_59268_DS1.pdf
• File Type:
  [PDF - 968.80 KB ]