Relationship of Systemic IL-10 Levels with Proinflammatory Cytokine Responsiveness and Lung Function in Agriculture Workers

Details

• Journal Article:
  Respiratory Research
• Personal Author:
  LeVan, Tricia D. ; Romberger, Debra J. ; Siahpush, Mohammad ; Grimm, Brandon L. ; Ramos, Athena K. ; Johansson, Patrik L. ; Michaud, Tzeyu L. ; Heires, Art J. ; Wyatt, Todd A. ; Poole, Jill A.
• Description:
  Background: Agriculture workers are exposed to microbial component- and particulate matter-enriched organic dust aerosols. Whereas it is clear that exposure to these aerosols can lead to lung inflammation, it is not known how inflammatory responses are resolved in some individuals while others develop chronic lung disease. Interleukin (IL)-10 is an immunomodulatory cytokine that is recognized as a potent anti-inflammatory and pro-resolving factor. The objective of this study was to determine whether there is a relationship of systemic IL-10 and proinflammatory responses and/or respiratory health effects in humans with prior agriculture exposure. Methods: This is a cross sectional study of 625 veterans with >2 years of farming experience. Whole blood was stimulated with or without organic dust and measured for IL-6, TNFalpha and IL-10. Participants underwent spirometry and respiratory symptoms were assessed by questionnaire. Results: We found that baseline IL-10 concentration from the whole blood assay was inversely associated with DeltaTNF-alpha (r = -0.63) and DeltaIL-6 (r = -0.37) levels. Results remained highly significant in the linear regression model after adjusting for age, sex, BMI, race, education, smoking status, and white blood cell count (DeltaTNF-alpha, p < 0.0001; DeltaIL-6, p < 0.0001). We found no association between chronic cough (p = 0.18), chronic phlegm (p = 0.31) and chronic bronchitis (p = 0.06) and baseline IL-10 levels using univariate logistic regression models. However, we did find that higher FEV1/FVC was significantly associated with increased baseline IL-10 concentration. Conclusions: Collectively, these studies support a potential role for IL-10 in modulating an inflammatory response and lung function in agriculture-exposed persons. Description provided by NIOSH
• Subjects:
  • Aerosols
  • Agriculture
  • Dust
  • Immune System
  • Lung
  • Microbiology
  • Occupational Health
  • Particulate Matter
  • Respiratory System
  • Respiratory Tract Diseases
  More +
• Keywords:
  • Organic dusts; Particulates; Aerosol particles; Aerosols; Microorganisms; Cytokines; Immune reaction; Agriculture workers; Agriculture; Exposure assessment; Lung function; Cross sectional studies; Questionnaires;
  • Author Keywords: Agriculture; IL-10; Organic dust; Airway disease
• Source:
  Respir Res 2018 Sep; 19:166
• ISSN:
  1465-9921
• Pubmed ID:
  30176916
• Pubmed Central ID:
  PMC6122449
• Document Type:
  Text
• Funding:
  no number/Biomedical Laboratory Research and Development, VA Office of Research and Development/ ; IK6 BX003781/BX/BLRD VA/United States ; CX000434/Biomedical Laboratory Research and Development, VA Office of Research and Development/ ; BX003781/Biomedical Laboratory Research and Development, VA Office of Research and Development/ ; ES019325/National Institute of Environmental Health Sciences/ ; R01 ES019325/ES/NIEHS NIH HHS/United States ; I01 CX000434/CX/CSRD VA/United States ; OH010162/National Institute for Occupational Safety and Health/ ; no number/National Institute for Occupational Safety and Health/ ; U54 OH010162/OH/NIOSH CDC HHS/United States
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7 pdf pages
• Volume:
  19
• NIOSHTIC Number:
  nn:20052770
• Contact Point Address:
  Tricia D. LeVan, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA
• Email:
  tlevan@unmc.edu
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Download URL:
  https://stacks.cdc.gov/view/cdc/59119/cdc_59119_DS1.pdf
• File Type:
  [PDF - 495.06 KB]
• Collection(s):
  National Institute for Occupational Safety and Health ; CDC Public Access
• Main Document Checksum:
  urn:sha-512:4186da7e134ca06c0e13626e77f246a07167497f819578debbccd40156158c0562b176fe1290f1bdf63983d0188ce59b05f85cc5f78e85f30431de68f15341fe