Relationship of systemic IL-10 levels with proinflammatory cytokine responsiveness and lung function in agriculture workers

Details

• Alternative Title:
  Respir Res
• Personal Author:
  LeVan, Tricia D. ; Romberger, Debra J. ; Siahpush, Mohammad ; Grimm, Brandon L. ; Ramos, Athena K. ; Johansson, Patrik L. ; Michaud, Tzeyu L. ; Heires, Art J. ; Wyatt, Todd A. ; Poole, Jill A.
• Description:
  Background
  
  Agriculture workers are exposed to microbial component- and particulate matter-enriched organic dust aerosols. Whereas it is clear that exposure to these aerosols can lead to lung inflammation, it is not known how inflammatory responses are resolved in some individuals while others develop chronic lung disease. Interleukin (IL)-10 is an immunomodulatory cytokine that is recognized as a potent anti-inflammatory and pro-resolving factor. The objective of this study was to determine whether there is a relationship of systemic IL-10 and proinflammatory responses and/or respiratory health effects in humans with prior agriculture exposure.
  
  Methods
  
  This is a cross sectional study of 625 veterans with > 2 years of farming experience. Whole blood was stimulated with or without organic dust and measured for IL-6, TNFα and IL-10. Participants underwent spirometry and respiratory symptoms were assessed by questionnaire.
  
  Results
  
  We found that baseline IL-10 concentration from the whole blood assay was inversely associated with ΔTNF-α (r = − 0.63) and ΔIL-6 (r = − 0.37) levels. Results remained highly significant in the linear regression model after adjusting for age, sex, BMI, race, education, smoking status, and white blood cell count (ΔTNF-α, p < 0.0001; ΔIL-6, p < 0.0001). We found no association between chronic cough (p = 0.18), chronic phlegm (p = 0.31) and chronic bronchitis (p = 0.06) and baseline IL-10 levels using univariate logistic regression models. However, we did find that higher FEV1/FVC was significantly associated with increased baseline IL-10 concentration.
  
  Conclusions
  
  Collectively, these studies support a potential role for IL-10 in modulating an inflammatory response and lung function in agriculture-exposed persons.
  
  
• Subjects:
  Agriculture Airway Disease IL-10 Organic Dust Research
• Source:
  Respir Res. 19.
• Pubmed ID:
  30176916
• Pubmed Central ID:
  PMC6122449
• Document Type:
  Journal Article
• Funding:
  no number/Biomedical Laboratory Research and Development, VA Office of Research and Development/ ; IK6 BX003781/BX/BLRD VA/United States ; CX000434/Biomedical Laboratory Research and Development, VA Office of Research and Development/ ; BX003781/Biomedical Laboratory Research and Development, VA Office of Research and Development/ ; ES019325/National Institute of Environmental Health Sciences/ ; R01 ES019325/ES/NIEHS NIH HHS/United States ; I01 CX000434/CX/CSRD VA/United States ; OH010162/National Institute for Occupational Safety and Health/ ; no number/National Institute for Occupational Safety and Health/ ; U54 OH010162/OH/NIOSH CDC HHS/United States
• Volume:
  19
• NIOSHTIC Number:
  nn:20052770
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4186da7e134ca06c0e13626e77f246a07167497f819578debbccd40156158c0562b176fe1290f1bdf63983d0188ce59b05f85cc5f78e85f30431de68f15341fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/59119/cdc_59119_DS1.pdf
• File Type:
  [PDF - 495.06 KB ]