Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences

Details

• Personal Author:
  Bauer C ; Gleason AM ; Golden GA ; McCaskill M ; Poole JA ; Reiff D ; Romberger DJ ; Wyatt TA
• Description:
  Exposure to organic dusts elicits airway inflammatory diseases. Vitamin D recently has been associated with various airway inflammatory diseases, but its role in agricultural organic dust exposures is unknown. This study investigated whether vitamin D reduces organic dust-induced inflammatory outcomes in cell culture and animal models. Organic dust extracts obtained from swine confinement facilities induced neutrophil chemokine production (human IL-8, murine CXCL1/CXCL2). Neutrophil chemokine induction was reduced in human blood monocytes, human bronchial epithelial cells, and murine lung slices pretreated with 1,25-(OH)(2) D(3) . Intranasal inhalation of organic dust extract induced neutrophil influx, and CXCL1/CXCL2 release was also decreased in mice fed a relatively high vitamin D diet as compared to mice fed a low vitamin D diet. These findings were associated with reduced tracheal epithelial cell PKCa and PKCe activity and whole lung TLR2 and TLR4 gene expression. Collectively, vitamin D plays a role in modulating organic dust-induced airway inflammatory outcomes. [Description provided by NIOSH]
• Subjects:
  Agriculture Dust Immune System Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Agricultural-workers Airway-obstruction Dust-exposure Dust-inhalation Immune-reaction Lung-cells Lung-irritants Neutrophils Organic-dusts Respiratory-system-disorders Vitamins

  More +
• ISSN:
  1095-6670
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  77-86
• Volume:
  27
• Issue:
  1
• NIOSHTIC Number:
  nn:20042169
• Citation:
  J Biochem Mol Toxicol 2013 Jan; 27(1):77-86
• Contact Point Address:
  Jill A. Poole, Pulmonary, Critical Care, Sleep and Allergy Division, Department of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5300, USA
• Email:
  japoole@unmc.edu
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  False
• Start Date:
  20110901
• Source Full Name:
  Journal of Biochemical and Molecular Toxicology
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c10366fa09434bac1585ba7126915be65558289a53332e9d9936bb4a882b219011700b113f629893810829a4347dc57e6fe2b027b9d658b99f86abd1894d5ed6
• Download URL:
  https://stacks.cdc.gov/view/cdc/194474/cdc_194474_DS1.pdf
• File Type:
  [PDF - 318.84 KB ]