Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kurhade, Chaitanya ; Schreier, Sarah ; Lee, Yi-Ping ; Zegenhagen, Loreen ; Hjertqvist, Marika ; Dobler, Gerhard ; Kröger, Andrea ; Överby, Anna K.
• Description:
  We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.
• Subjects:
  Arboviral Diseases Correlation Of Severity Of Human Tick-Borne Encephalitis Virus Disease And Pathogenicity In Mice Dispatch Flavivirus Pathogenesis Tick-borne Encephalitis Tick-borne Encephalitis Virus Ticks Vector-borne Infections Viruses
• Source:
  Emerg Infect Dis. 24(9):1709-1712.
• Pubmed ID:
  30124404
• Pubmed Central ID:
  PMC6106420
• Document Type:
  Journal Article
• Place as Subject:
  Germany ; Sweden
• Location:
  Europe
• Volume:
  24
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:49af892ef68870fbeb91ffa82331d9e7ae7961da3c7bd29a7fa898d539dac6c1
• Download URL:
  https://stacks.cdc.gov/view/cdc/58640/cdc_58640_DS1.pdf
• File Type:
  [PDF - 1.08 MB ]