Use of Favipiravir to Treat Lassa Virus Infection in Macaques

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rosenke, Kyle ; Feldmann, Heinz ; Westover, Jonna B. ; Hanley, Patrick William ; Martellaro, Cynthia ; Feldmann, Friederike ; Saturday, Greg ; Lovaglio, Jamie ; Scott, Dana P. ; Furuta, Yousuke ; Komeno, Takashi ; Gowen, Brian B. ; Safronetz, David
• Description:
  Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection. We tested favipiravir in Lassa virus-viremic macaques and found that 300 mg/kg daily for 2 weeks successfully treated infection.
• Subjects:
  Dispatch Use Of Favipiravir To Treat Lassa Virus Infection In Macaques
• Source:
  Emerg Infect Dis. 24(9):1696-1699.
• Pubmed ID:
  29882740
• Pubmed Central ID:
  PMC6106425
• Document Type:
  Journal Article
• Volume:
  24
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:231a235f42a9857496c04a42a769a855226ef10f925e24ff7da48e62293f0e8c
• Download URL:
  https://stacks.cdc.gov/view/cdc/58628/cdc_58628_DS1.pdf
• File Type:
  [PDF - 2.14 MB ]