Within-Day, Between-Day, and Between-Week Variability of Urinary Concentrations of Phenol Biomarkers in Pregnant Women

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Vernet, Céline ; Philippat, Claire ; Calafat, Antonia M. ; Ye, Xiaoyun ; Lyon-Caen, Sarah ; Siroux, Valérie ; Schisterman, Enrique F. ; Slama, Rémy
• Description:
  Background:
  
  Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized.
  
  Objectives:
  
  We aimed to characterize within-day, between-day, and between-week variability of phenol urinary biomarker concentrations during pregnancy.
  
  Methods:
  
  In eight French pregnant women, we collected all urine voids over a 1-wk period (average, 60 samples per week per woman) at three occasions (15±2, 24±2, and 32±1 gestational weeks) in 2012–2013. Aliquots of each day and of the whole week were pooled within-subject. We assayed concentrations of 10 phenols in these pools, and, for two women, in all spot (unpooled) samples collected during a 1-wk period. We characterized variability using intraclass correlation coefficients (ICCs) with spot samples (within-day variability), daily pools (between-day variability), and weekly pools (between-week variability).
  
  Results:
  
  For most biomarkers, the within-day variability was high (ICCs between 0.03 and 0.50). The between-day variability, based on samples pooled within each day, was much lower, with ICCs >0.60 except for bisphenol S (0.14, 95% confidence interval [CI]: 0.00, 0.39). The between-week variability differed between compounds, with triclosan and bisphenol S having the lowest ICCs (<0.3) and 2,5-dichlorophenol the highest (ICC >0.9).
  
  Conclusion:
  
  During pregnancy, phenol biomarkers showed a strong within-day variability, while the variability between days of a given week was more limited. One biospecimen is not enough to efficiently characterize exposure; collecting biospecimens during a single week may be enough to represent well the whole pregnancy exposure for some but not all phenols. https://doi.org/10.1289/EHP1994
  
  
• Subjects:
  Research
• Source:
  Environ Health Perspect. 126(3).
• Pubmed ID:
  29553460
• Pubmed Central ID:
  PMC6071804
• Document Type:
  Journal Article
• Funding:
  311765/European Research Council/International
• Volume:
  126
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:55f27fa57572abb7b68fa87dd2650fa1ca40990d712cfbb6a9aefc0c4379062b
• Download URL:
  https://stacks.cdc.gov/view/cdc/58261/cdc_58261_DS1.pdf
• File Type:
  [PDF - 623.68 KB ]