A Population-Based Surveillance Study of Shared Genotypes of Escherichia coli Isolates from Retail Meat and Suspected Cases of Urinary Tract Infections

Details

• Alternative Title:
  mSphere
• Personal Author:
  Yamaji, Reina ; Friedman, Cindy R. ; Rubin, Julia ; Suh, Joy ; Thys, Erika ; McDermott, Patrick ; Hung-Fan, Melody ; Riley, Lee W.
• Description:
  There is increasing evidence that retail food may serve as a source of | that causes community-acquired urinary tract infections, but the impact of this source in a community is not known. We conducted a prospective, population-based study in one community to examine the frequency of recovery of uropathogenic | genotypes from retail meat samples. We analyzed | isolates from consecutively collected urine samples of patients suspected to have urinary tract infections (UTIs) at a university-affiliated health service and retail meat samples from the same geographic region. We genotyped all | isolates by multilocus sequence typing (MLST) and tested them for antimicrobial susceptibility. From 2016 to 2017, we cultured 233 | isolates from 230 (21%) of 1,087 urine samples and 177 | isolates from 120 (28%) of 427 retail meat samples. Urine samples contained 61 sequence types (STs), and meat samples had 95 STs; 12 STs (ST10, ST38, ST69, ST80, ST88, ST101, ST117, ST131, ST569, ST906, ST1844, and ST2562) were common to both. Thirty-five (81%) of 43 meat isolates among the 12 STs were from poultry. Among 94 isolates in the 12 STs, 26 (60%) of 43 retail meat isolates and 15 (29%) of 51 human isolates were pan-susceptible (| 0.005). We found that 21% of | isolates from suspected cases of UTIs belonged to STs found in poultry. Poultry may serve as a possible reservoir of uropathogenic | (UPEC). Additional studies are needed to demonstrate transmission pathways of these UPEC genotypes and their food sources.| Community-acquired urinary tract infection caused by | is one of the most common infectious diseases in the United States, affecting approximately seven million women and costing approximately 11.6 billion dollars annually. In addition, antibiotic resistance among | bacteria causing urinary tract infection continues to increase, which greatly complicates treatment. Identifying sources of uropathogenic | and implementing prevention measures are essential. However, the reservoirs of uropathogenic | have not been well defined. This study demonstrated that poultry sold in retail stores may serve as one possible source of uropathogenic | This finding adds to a growing body of evidence that suggests that urinary tract infection may be a food-borne disease. More research in this area can lead to the development of preventive strategies to control this common and costly infectious disease.
• Subjects:
  Escherichia Coli Extraintestinal Diseases Molecular Epidemiology Multidrug Resistance Multilocus Sequence Typing Research Article Urinary Tract Infection Uropathogenic E. Coli
• Source:
  mSphere. 2018; 3(4).
• Pubmed ID:
  30111626
• Pubmed Central ID:
  PMC6094058
• Document Type:
  Journal Article
• Volume:
  3
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:19eaf750372308fddacbd1532b772f0b5914d2de586766274a5ed19ac2cd0140
• Download URL:
  https://stacks.cdc.gov/view/cdc/58235/cdc_58235_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]