Direct Detection of Carbapenem-Resistant Organisms from Environmental Samples Using the GeneXpert Molecular Diagnostic System

Perry, K. A.; Daniels, J. B.; Reddy, S. C.; Kallen, A. J.; Halpin, A. L.; Rasheed, J. K.; Noble-Wang, J. A.

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Direct Detection of Carbapenem-Resistant Organisms from Environmental Samples Using the GeneXpert Molecular Diagnostic System

Aug 01 2018
By Perry, K. A. ; Daniels, J. B. ; Reddy, S. C. ; ...
Source: mSphere. 3(4).

[PDF-171.28 KB]

English

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Details:

Alternative Title:

mSphere
Personal Author:

Perry, K. A. ; Daniels, J. B. ; Reddy, S. C. ; Kallen, A. J. ; Halpin, A. L. ; ... More +

Perry, K. A. ; Daniels, J. B. ; Reddy, S. C. ; Kallen, A. J. ; Halpin, A. L. ; Rasheed, J. K. ; Noble-Wang, J. A. Less -
Description:

In this pilot study, traditional culture and PCR methods were compared to the Cepheid GeneXpert IV molecular diagnostic system with the Xpert Carba-R assay (Carba-R assay) for detection of carbapenem resistance genes in primary environmental samples collected during a health care-related outbreak. Overall, traditional culture-dependent PCR and the Carba-R assay demonstrated 75% agreement. The Carba-R assay detected carbapenemase genes in five additional samples and in two samples that had additional genes when compared to culture-dependent PCR. The Carba-R assay could be useful for prioritizing further testing of environmental samples during health care-related outbreaks.| Use of the Carba-R assay for detection of carbapenem-resistant Gram-negative organisms (CROs) can provide data for implementation of a rapid infection control response to minimize the spread of CROs in the health care setting.
Subjects:

[+]

Carbapenemase Genes Carbapenem Resistant Cepheid GeneXpert Observation PCR
Source:

mSphere. 3(4).
Pubmed ID:

30068556
Pubmed Central ID:

PMC6070738
Document Type:

Journal Article
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:fb5d3e15986d8ab1cbc2cff1a51f9188b7b6cc472d714bfa3995b22fc84b7b33
Download URL:

https://stacks.cdc.gov/view/cdc/58234/cdc_58234_DS1.pdf
File Type:

mSphere.00113-18.nxml

xml

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