Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Inoue, Juliana ; Silva, Miguel ; Fofana, Bakary ; Sanogo, Kassim ; Mårtensson, Andreas ; Sagara, Issaka ; Björkman, Anders ; Veiga, Maria Isabel ; Ferreira, Pedro Eduardo ; Djimde, Abdoulaye ; Gil, José Pedro
• Description:
  Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
• Subjects:
  Antimalarials Artemisinins Aspartic Acid Endopeptidases Drug Combinations Drug Resistance Humans Malaria, Falciparum Pilot Projects Quinolines
• Source:
  Emerg Infect Dis. 24(8):1591-1593
• Pubmed ID:
  29798744
• Pubmed Central ID:
  PMC6056108
• Document Type:
  Journal Article
• Funding:
  Medical Research Council/United Kingdom
• Genre:
  Letter
• Place as Subject:
  Mali
• Volume:
  24
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e457d1420e6def97e14adfb153666b44966f8875134a09d51ff65c7ce7d9219e
• Download URL:
  https://stacks.cdc.gov/view/cdc/57979/cdc_57979_DS1.pdf
• File Type:
  [PDF - 416.56 KB ]