Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lee, Joon Kee ; Lee, Joon Ho ; Lee, Hyunju ; Ahn, Young Min ; Eun, Byung Wook ; Cho, Eun Young ; Cho, Hwa Jin ; Yun, Ki Wook ; Lee, Hoan Jong ; Choi, Eun Hwa
• Description:
  To investigate the genetic background for the emergence of macrolide resistance, we characterized the genetic features of Mycoplasma pneumoniae using multilocus sequence typing. Of the 146 M. pneumoniae strains collected during the 5 consecutive outbreaks of M. pneumoniae pneumonia during 2000-2016 in South Korea, macrolide resistance increased from 0% in the first outbreak to 84.4% in the fifth. Among the 8 sequence types (STs) identified, ST3 (74.7%) was the most prevalent, followed by ST14 (15.1%). Macrolide-susceptible strains comprised 8 different STs, and all macrolide-resistant strains were ST3 (98.3%) except 1 with ST14. The proportion of macrolide-resistant strains in ST3 remained 2.2% (1/46) until the 2006-2007 outbreak and then markedly increased to 82.6% (19/23) during the 2010-2012 outbreak and 95.0% (38/40) during the 2014-2016 outbreak. The findings demonstrated that clonal expansion of ST3 M. pneumoniae was associated with the increase in macrolide resistance in South Korea.
• Subjects:
  Anti-Bacterial Agents Child Disease Outbreaks Humans Macrolides Multilocus Sequence Typing Pneumonia, Mycoplasma Republic Of Korea Research Retrospective Studies
• Source:
  Emerg Infect Dis. 24(8):1465-1471
• Pubmed ID:
  30014844
• Pubmed Central ID:
  PMC6056092
• Document Type:
  Journal Article
• Place as Subject:
  Republic of Korea
• Location:
  Asia
• Volume:
  24
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2c341fe3f00b4a9ae67228f7e8dde2422b61512f24b9930e078c7a07525280dc
• Download URL:
  https://stacks.cdc.gov/view/cdc/57964/cdc_57964_DS1.pdf
• File Type:
  [PDF - 742.12 KB ]