Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Phan, Nga Thi ; Gouilh, Meriadeg Ar ; Paireau, Juliette ; Phuong, Loan ; Cheval, Justine ; ... More +
Phan, Nga Thi ; Gouilh, Meriadeg Ar ; Paireau, Juliette ; Phuong, Loan ; Cheval, Justine ; Ngu, Nghia Duy ; Hébert, Charles ; Nguyen, Tuan Hai ; Lortholary, Olivier ; Tondeur, Laura ; Manuguerra, Jean-Claude ; Barouki, Robert ; Sander, Johannes ; Janzen, Nils ; Nguyen, Hien Tran ; Brey, Paul T. ; Fontanet, Arnaud ; Eloit, Marc ; Less -
Description:
We investigated the cause of seasonal outbreaks of pediatric acute encephalitis-like syndrome associated with litchi harvests (May-July) in northern Vietnam since 2008. Nineteen cerebrospinal fluid samples were positive for human enterovirus B, and 8 blood samples were positive for hypoglycemic toxins present in litchi fruits. Patients who were positive for hypoglycemic toxins had shorter median times between disease onset and admission, more reports of seizures, more reports of hypoglycemia (glucose level <3 mmol/L), lower median numbers of leukocytes in cerebrospinal fluid, and higher median serum levels of alanine aminotransferase and aspartate transaminase than did patients who were positive for enteroviruses. We suggest that children with rapidly progressing acute encephalitis-like syndrome at the time of the litchi harvest have intoxication caused by hypoglycemic toxins, rather than viral encephalitis, as previously suspected. These children should be urgently treated for life-threatening hypoglycemia.
Subject:
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Acute Febrile Encephalopathy
Child
Child, Preschool
Enterovirus
Enterovirus Infections
Female
Humans
Infant
Male
Research
Retrospective Studies
Seasons

Source:
Emerg Infect Dis. 24(8):1435-1443
Pubmed ID:
30014832
Pubmed Central ID:
PMC6056107
Document Type:
Journal Article ;
Place as Subject:
Vietnam ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:c8026458d54b48f9c9251344f496893ae3165820c1f339a828df123eec6b186e
File Type:

Supporting Files

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