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Reagent substitutions in the Centers for Disease Control and Prevention Nijmegen-Bethesda assay for factor VIII inhibitors
  • Published Date:
    Mar 24 2018
  • Source:
    Haemophilia. 24(3):e116-e119.
  • Language:
    English
Filetype[PDF-141.16 KB]


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    BackgroundThe Bethesda assay (BA) for measurement of factor VIII (FVIII) inhibitors called for quantitation of positive inhibitors using dilutions producing 25–75% residual activity (RA), corresponding to 0.4–2.0 Bethesda units, recommending use ...
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  5. Comparison of Clot-based, Chromogenic, and Fluorescence Assays for Measurement of Factor VIII Inhibitors in the U.S. Hemophilia Inhibitor Research Study
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    Miller, Connie H.; Rice, Anne S.; Boylan, Brian; Shapiro, Amy D.; Lentz, Steven R.; Wicklund, Brian M.; Kelly, Fiona M.; Soucie, J. Michael;
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    J Thromb Haemost. 11(7):1300-1309.
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    BackgroundDetection and validation of inhibitors (antibodies) to hemophilia treatment products are important for clinical care, evaluation of product safety, and assessment of population trends.MethodsCentralized monitoring for factor VIII (FVIII) in...
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