Details:

Alternative Title:
J Rheumatol
Personal Author:
Herzog, Mackenzie M. ; Driban, Jeffrey B. ; Cattano, Nicole M. ; Cameron, Kenneth L. ; Tourville, Timothy W. ; ... More +
Herzog, Mackenzie M. ; Driban, Jeffrey B. ; Cattano, Nicole M. ; Cameron, Kenneth L. ; Tourville, Timothy W. ; Marshall, Stephen W ; Pietrosimone, Brian Less -
Description:
Objective:

To assess the association between change in walking speed over a 12-month period and risk of developing radiographic knee osteoarthritis (rKOA) over a 24-month period.

Methods:

We included participants without rKOA from the Osteoarthritis Initiative. Change in walking speed was determined from a 20-meter walk assessment, calculated using walking speed at 12-month follow-up minus baseline speed and/or 24-month follow-up walking speed minus 12-month speed. Incident rKOA was defined as progressing to Kellgren-Lawrence grade ≥2 within 24 months (i.e., incidence between 12 and 36 or 24 and 48 months). Self-reported significant knee injury during the exposure period, age, body mass index (BMI), and Physical Activity Scale for the Elderly (PASE) score were adjusted for analytically.

Results:

We included 2,638 observations among 1,460 unique participants (58% female; 59±9 years, range: 45–79). The mean change in walking speed over 12 months was 0.001±0.13 m/s (range: −0.6271, 1.4968). Approximately 5% of the sample (n=122) developed rKOA over a 24-month period. After controlling for significant knee injury, age, BMI, and PASE score, we found an 8% relative increase in risk of developing rKOA for every 0.1m/s decrease in walking speed over a 12-month period (Risk Ratio=1.08; 95% CI =1.00, 1.15; P = 0.05).

Conclusion:

Evaluating change in speed over a 12-month period using a 20-meter walk test may be useful in identifying individuals at increased risk of developing rKOA over the subsequent 24-months. Identification of patients at high risk for developing rKOA would allow medical providers to implement early interventions to maximize joint health.


Subject:
[+]
Aged
Article
Body Mass Index
Female
Gait
Humans
Knee
Knee Joint
Male
Middle Aged
Osteoarthritis
Osteoarthritis, Knee
Risk Factors
Trauma Severity Indices
Walking
Walking Speed

Source:
J Rheumatol. 44(8):1265-1270.
Pubmed ID:
28572470
Pubmed Central ID:
PMC6061917
Document Type:
Journal Article
Funding:
R49 CE002479/CE/NCIPC CDC HHS/United States ; N01 AR022261/AR/WHI NIH HHS/United States ; N01 AR022258/AR/WHI NIH HHS/United States ; N01 AR022259/AR/WHI NIH HHS/United States ; N01 AR022262/AR/WHI NIH HHS/United States ; ... More +
R49 CE002479/CE/NCIPC CDC HHS/United States ; N01 AR022261/AR/WHI NIH HHS/United States ; N01 AR022258/AR/WHI NIH HHS/United States ; N01 AR022259/AR/WHI NIH HHS/United States ; N01 AR022262/AR/WHI NIH HHS/United States ; N01 AR022260/AR/WHI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:bcfe1dc2ab0caa97da6047971901be938f8fb6c8a7db8581b6f6db296f314eaa
File Type:

Supporting Files

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