The association between walking speed from short- and standard-distance tests with the risk of all-cause mortality among adults with radiographic knee osteoarthritis: Data from three large United States cohort studies

Details

• Alternative Title:
  Osteoarthritis Cartilage
• Personal Author:
  Master, Hiral ; Neogi, Tuhina ; Callahan, Leigh F. ; Nelson, Amanda E. ; LaValley, Michael ; Cleveland, Rebecca J. ; Golightly, Yvonne M. ; Thoma, Louise M. ; Zhang, Yuqing ; Voinier, Dana ; Christiansen, Meredith B. ; Jakiela, Jason T. ; Nevitt, Michael ; Lewis, Cora E. ; Frey-Law, Laura A. ; White, Daniel K.
• Description:
  Objective
  
  Adults with radiographic knee OA (rKOA) are at increased risk of mortality and walking difficulty may modify this relation. Little is known about specific aspects of walking difficulty that increase mortality risk. We investigated the association of walking speed (objective measure of walking difficulty) with mortality and examined the threshold that best discriminated this risk in adults with rKOA.
  
  Methods
  
  Participants with rKOA from the Johnston County Osteoarthritis Project (JoCoOA, longitudinal population-based cohort), Osteoarthritis Initiative and Multicenter Osteoarthritis Study (OAI and MOST, cohorts of individuals with or at high risk of knee OA) were included. Baseline speed was measured via 2.4-meter (m) walk test (short-distance) in JoCoOA and 20-m walk test (standard-distance) in OAI and MOST. To examine the association of walking speed with mortality risk over nine years, hazard ratios (aHR) and 95% confidence intervals (CI) were calculated from Cox regression models adjusted for potential confounders., A Maximal Likelihood Ratio Chi-square Approach was utilized to identify an optimal threshold of walking speed predictive of mortality.
  
  Results
  
  Deaths after 9 years of follow-up occurred in 23.3% (290/1244) of JoCoOA and 5.9% (249/4215) of OAI+MOST. Walking 0.2 meters/second slower during short- and standard-distance walk tests was associated with 23% (aHR[95%CI]; 1.23[1.10, 1.39]) and 25% (1.25[1.09, 1.43]) higher mortality risk, respectively. Walking <0.5 meters/second on short-distance and <1.2 meters/second standard-distance walk tests, best discriminated those with and without mortality risk.
  
  Conclusion
  
  Slower walking speed measured via short- and standard-distance walk tests was associated with increased mortality risk in adults with rKOA.
  
  
• Subjects:
  Aged Cohort Studies Female Humans Longitudinal Studies Male Middle Aged Mortality Osteoarthritis, Knee United States Walking Speed

  More +
• Keywords:
  Arthritis Death Gait Speed Performance-based Measures Physical Function
• Source:
  Osteoarthritis Cartilage. 28(12):1551-1558
• Pubmed ID:
  32861851
• Pubmed Central ID:
  PMC7722103
• Document Type:
  Journal Article
• Funding:
  K24 AR070892/AR/NIAMS NIH HHSUnited States/ ; U01 AG018947/AG/NIA NIH HHSUnited States/ ; T32 HD007490/HD/NICHD NIH HHSUnited States/ ; U01 AG018832/AG/NIA NIH HHSUnited States/ ; R01 AR065937/AR/NIAMS NIH HHSUnited States/ ; P30 AR072571/AR/NIAMS NIH HHSUnited States/ ; F32 AR073090/AR/NIAMS NIH HHSUnited States/ ; P30 AR072580/AR/NIAMS NIH HHSUnited States/ ; U01 AG019069/AG/NIA NIH HHSUnited States/ ; U01 AG018820/AG/NIA NIH HHSUnited States/ ; K23 AR070913/AR/NIAMS NIH HHSUnited States/ ; R21 AR071079/AR/NIAMS NIH HHSUnited States/ ; P60 AR064166/AR/NIAMS NIH HHSUnited States/ ; K12 HD055931/HD/NICHD NIH HHSUnited States/ ; U54 GM104941/GM/NIGMS NIH HHSUnited States/ ; U01DP003206/ACL/ACL HHSUnited States/
• Volume:
  28
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6a79aa8340bb3258b10c31de160dd7261fef056f565493207bc3a2da20969577
• Download URL:
  https://stacks.cdc.gov/view/cdc/158035/cdc_158035_DS1.pdf
• File Type:
  [PDF - 561.04 KB ]