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Hemochromatosis; an iron overload disease
  • Published Date:
    July 2003
Filetype[PDF-250.65 KB]


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    Clinical penetrance in hereditary hemochromatosis: estimates of the cumulative incidence of severe liver disease among HFE C282Y homozygotes
    Personal Author:
    Grosse, Scott D.; Gurrin, Lyle C.; Bertalli, Nadine A.; Allen, Katrina J.;
    Published:
    Aug 03 2017
    Source:
    Genet Med. 20(4):383-389.
    Description:
    Iron overload (hemochromatosis) can cause serious, symptomatic disease that is preventable if detected early and managed appropriately. The leading cause of hemochromatosis in populations of predominantly European ancestry is homozygosity of the C282...
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  2. Telomere length and elevated iron: The influence of phenotype and HFE genotype
    Personal Author:
    Mainous, Arch G.; Wright, Robert U.; Hulihan, Mary M.; Twal, Waleed O.; McLaren, Christine E.; Diaz, Vanessa A.; McLaren, Gordon D.; Argraves, W. Scott; Grant, Althea M.;
    Published:
    May 13 2013
    Source:
    Am J Hematol. 2013; 88(6):492-496.
    Description:
    Elevated body iron stores are associated with morbidity and mortality due to oxidative stress. Hereditary hemochromatosis, a common condition caused by HFE gene mutations, can lead to excess iron storage and disease but clinical penetrance of HFE gen...
    File Type:
    Filetype[PDF - 173.75 KB]
  3. Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain
    Personal Author:
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    Published:
    Jan 28 2010
    Source:
    Ann Hematol. 89(8):767-773.
    Description:
    Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can incre...
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    Mainous, Arch G.; Wright, Robert U.; Hulihan, Mary M.; Twal, Waleed O.; McLaren, Christine E.; Diaz, Vanessa A.; McLaren, Gordon D.; Argraves, W. Scott; Grant, Althea M.;
    Published:
    Dec 15 2013
    Source:
    Biometals. 27(1):135-141.
    Description:
    We sought to examine the relationship between elevated transferrin saturation (TS) and measures of health status (telomere length and patient-reported health-related quality of life) to assess whether elevated TS is associated with negative patient o...
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  5. MMWR. Morbidity and mortality weekly report, Vol. 45, no. 45, November 15, 1996
    Corporate Author:
    Centers for Disease Control and Prevention (U.S.)
    Published:
    November 15, 1996
    Series:
    MMWR. Morbidity and mortality weekly report ; v. 45, no. 45
    File Type:
    Filetype[PDF - 231.54 KB]