NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings 2010

Details

• Alternative Title:
  List of antineoplastic and other hazardous drugs in healthcare settings 2010
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In this Alert, NIOSH presents a standard precautions or universal precautions approach to handling hazardous drugs safely: that is, NIOSH recommends that all hazardous drugs be handled as outlined in this Alert. Therefore, no attempt has been made to perform drug risk assessments or propose exposure limits. The area of new drug development is rapidly evolving as unique approaches are being taken to treat cancer and other serious diseases.
  
  "The National Institute for Occupational Safety and Health (NIOSH) Alert: Preventing Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings was published in September 2004 (http://www.cdc.gov/niosh/docs/2004-165/). In Appendix A of the Alert, NIOSH identified a sample list of major hazardous drugs. The list was compiled from information provided by four institutions that have generated lists of hazardous drugs for their respective facilities and by the Pharmaceutical Research and Manufacturers of America (PhRMA) from the American Hospital Formulary Service Drug Information (AHFS DI) monographs [ASHP/AHFS DI 2003]. This update adds 21 drugs to the original list in the 2004 Alert. These additions are new drugs or existing drugs that had new warnings from 2004 to 2007. The review process for the addition of the new listings is described in the Federal Register: http://www.cdc.gov/niosh/docket/review/docket105.html and http://www.cdc.gov/niosh/docket/review/docket105a.html. This document was sunset in June 2012.
  
  The NIOSH List of Hazardous Drugs in Healthcare Settings is a tool designed to assist healthcare workers and employers in identifying which drugs routinely handled by employees are considered by NIOSH to be hazardous drugs.
  
  The NIOSH Alert: Preventing Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings (NIOSH Pub No 2004-165) was first published in 2004. The document identified a sample list of major hazardous drugs. The list was compiled from information provided by four institutions that had generated lists of hazardous drugs for their respective institutions, as well as a list from the Pharmaceutical Research and Manufacturers of America). The 2004 list was updated in 2010, 2012 and 2014, 2016 and 2024. Some of the updates include:
  
  The 2010 update (NIOSH Pub No 2010—167) added 21 drugs to the original list in the 2004 Alert. Additional information for the 2010 update can be found at Peer review and public comment.
  
  The 2014 update (NIOSH Pub No 2014—138) added 27 drugs and includes a review of the 2004 list and the consequent removal of 12 drugs that did not meet the NIOSH criteria for hazardous drugs.
  
  The 2016 update (NIOSH Pub No 2016—161) added 34 drugs and includes a review of the 2004 list. This list includes drugs reviewed by NIOSH from January 2012 to December 2013. Additional information for the 2016 update can be found at Federal Register Notice.
  
  The 2024 update (NIOSH Pub No 2025—103) added 25 drugs, 12 with manufacturer’s special handling information, and removed 7 drugs.
  
  
• Content Notes:
  Series Name added retrospectively to efficiently organize past and current materials related to the "NIOSH List of Hazardous Drugs in Healthcare Setting." The Series Name does no appear on the document.
• Subjects:
  Antineoplastic Agents / Poisoning Hazardous Substances Health Care Facilities Workforce And Services Health Personnel Occupational Exposure / Prevention & Control Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Antineoplastic Agents Hazardous Drugs Hazards Health Care Facilities Health Care Personnel
• Series:
  Hazardous Drugs in Healthcare Settings   ; NIOSH Numbered Publications  
• DOI:
  https://doi.org/10.26616/NIOSHPUB2010167
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  United States
• Rights:
  Public Domain
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  17 pdf pages
• NIOSHTIC Number:
  nn:20037611
• NTIS Accession Number:
  PB2011-100009
• Citation:
  NIOSH [2010]. NIOSH list of antineoplastic and other hazardous drugs in healthcare settings 2010. By U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication Number 2010−167
• CAS Registry Number:
  Cyclophosphamide (CAS RN 50-18-0) ; Paclitaxel (CAS RN 33069-62-4) ; Ifosfamide (CAS RN 3778-73-2) ; Doxorubicin (CAS RN 23214-92-8) ; 5-Fluorouracil (CAS RN 51-21-8)
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:43e82d46ff5e083569c48ad7ef19a19fe93e3eec775b3253b56e241f6a118b012b19ae12b3a36dddbd09d944d944c022f8a4e05249a407a264b86e37d4f82ec9
• Download URL:
  https://stacks.cdc.gov/view/cdc/5743/cdc_5743_DS1.pdf
• File Type:
  [PDF - 7.88 MB ]