Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bougard, Daisy ; Bélondrade, Maxime ; Mayran, Charly ; Bruyère-Ostells, Lilian ; Lehmann, Sylvain ; Fournier-Wirth, Chantal ; Knight, Richard S. ; Will, Robert G. ; Green, Alison J.E.
• Description:
  A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported. Using an ultrasensitive and specific protein misfolding cyclic amplification-based assay for detecting variant CJD prions in cerebrospinal fluid, we discriminated this heterozygous case of variant CJD from cases of sporadic CJD.
• Subjects:
  Cerebrospinal Fluid CJD Creutzfeldt-Jakob Disease CSF Diagnosis Diagnosis Of Methionine/Valine Variant Creutzfeldt-Jakob Disease By Protein Misfolding Cyclic Amplification Dispatch GCJD Genetic Creutzfeldt-Jakob Disease Methionine/valine Variant PMCA Prions And Related Diseases Protein Misfolding Cyclic Amplification SCJD Sporadic Creutzfeldt-Jakob Disease Variant Creutzfeldt-Jakob Disease VCJD

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• Source:
  Emerg Infect Dis. 24(7):1364-1366.
• Pubmed ID:
  29912702
• Pubmed Central ID:
  PMC6038758
• Document Type:
  Journal Article
• Volume:
  24
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6950ab7ba23f8f4e8783f1cb2e87e550f5de804d8e6d729631a64d31aaeecaf8
• Download URL:
  https://stacks.cdc.gov/view/cdc/56947/cdc_56947_DS1.pdf
• File Type:
  [PDF - 357.21 KB ]