Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Bougard, Daisy; Bélondrade, Maxime; Mayran, Charly; Bruyère-Ostells, Lilian; Lehmann, Sylvain; Fournier-Wirth, Chantal; Knight, Richard S.; Will, Robert G.; Green, Alison J.E.

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Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Published Date:

Jul 2018

Source:

Emerg Infect Dis. 24(7):1364-1366.

Language:

English

[PDF-357.21 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Bougard, Daisy ; Bélondrade, Maxime ; Mayran, Charly ; Bruyère-Ostells, Lilian ; Lehmann, Sylvain ; ... More ▼

Description:

A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported. Using an ultrasensitive and specific protein misfolding cyclic amplification-based assay for detecting variant CJD prions in cerebrospinal fluid, we discriminated this heterozygous case of variant CJD from cases of sporadic CJD.

Subject:

[+]

Pubmed ID:

29912702

Pubmed Central ID:

PMC6038758

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	17-2105-F.gif	image/gif
	17-2105-F.jpg	image/jpeg
	17-2105.nxml	text/xml

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