Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Kenyon, Chris R. ; Schwartz, Ilan S.
Kenyon, Chris R. ; Schwartz, Ilan S. Less -
Description:
Contemporary strategies to curtail the emergence of antimicrobial resistance in Neisseria gonorrhoeae include screening for and treating asymptomatic infections in high-prevalence populations in whom antimicrobial drug-resistant infections have typically emerged. We argue that antimicrobial resistance in these groups is driven by a combination of dense sexual network connectivity and antimicrobial drug exposure (for example, through screen-and-treat strategies for asymptomatic N. gonorrhoeae infection). Sexual network connectivity sustains a high-equilibrium prevalence of N. gonorrhoeae and increases likelihood of reinfection, whereas antimicrobial drug exposure results in selection pressure for reinfecting N. gonorrhoeae strains to acquire antimicrobial resistance genes from commensal pharyngeal or rectal flora. We propose study designs to test this hypothesis.
Subject:
[+]
Antimicrobial Resistance
Bacteria
Core Groups
Effects Of Sexual Network Connectivity And Antimicrobial Drug Use On Antimicrobial Resistance In Neisseria Gonorrhoeae
Men Who Have Sex With Men
MSM
Neisseria Gonorrhoeae
Perspective
Sexually Transmitted Infections
Sexual Networks

Source:
Emerg Infect Dis. 24(7):1195-1203.
Pubmed ID:
29912682
Pubmed Central ID:
PMC6038757
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:5c42f7ed48041d5e0037bea045d848aa75901f9422059873c532d79201f6713e
File Type:

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