Large Outbreaks of Fungal and Bacterial Bloodstream Infections in a Neonatal Unit, South Africa, 2012–2016

van Schalkwyk, Erika; Iyaloo, Samantha; Naicker, Serisha D.; Maphanga, Tsidiso G.; Mpembe, Ruth S.; Zulu, Thokozile G.; Mhlanga, Mabatho; Mahlangu, Sibongile; Maloba, Motlatji B.; Ntlemo, Grace; Sanyane, Kgomotso; Mawela, Dini; Govender, Nelesh P.

i

Large Outbreaks of Fungal and Bacterial Bloodstream Infections in a Neonatal Unit, South Africa, 2012–2016

Supporting Files Public Domain

Jul 2018
By van Schalkwyk, Erika ; Iyaloo, Samantha ; Naicker, Serisha D. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

van Schalkwyk, Erika ; Iyaloo, Samantha ; Naicker, Serisha D. ; Maphanga, Tsidiso G. ; Mpembe, Ruth S. ; Zulu, Thokozile G. ; Mhlanga, Mabatho ; Mahlangu, Sibongile ; Maloba, Motlatji B. ; Ntlemo, Grace ; Sanyane, Kgomotso ; Mawela, Dini ; Govender, Nelesh P.
Description:

Candidemia is a major cause of healthcare-associated infections. We describe a large outbreak of Candida krusei bloodstream infections among infants in Gauteng Province, South Africa, during a 4-month period; a series of candidemia and bacteremia outbreaks in the neonatal unit followed. We detected cases by using enhanced laboratory surveillance and audited hospital wards by environmental sampling and epidemiologic studies. During July-October 2014, among 589 patients, 48 unique cases of C. krusei candidemia occurred (8.2% incidence). Risk factors for candidemia on multivariable analyses were necrotizing enterocolitis, birthweight <1,500 g, receipt of parenteral nutrition, and receipt of blood transfusion. Despite initial interventions, outbreaks of bloodstream infection caused by C. krusei, rarer fungal species, and bacterial pathogens continued in the neonatal unit through July 29, 2016. Multiple factors contributed to these outbreaks; the most functional response is to fortify infection prevention and control.
Subjects:

Bacteremia Child Cross Infection Disease Outbreaks Female Fungemia History, 21St Century Humans Infant, Newborn Infant, Newborn, Diseases Male Public Health Surveillance Risk Factors
Source:

Emerg Infect Dis. 24(7):1204-1212.
Pubmed ID:

29912684
Pubmed Central ID:

PMC6038734
Document Type:

Journal Article
Genre:

Historical Article
Place as Subject:

South Africa
Location:

Africa
Volume:

24
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d94931f55ab52cd800665daee6b9266a178b3636b89c2d24c9df60b59f4d40ed
Download URL:

https://stacks.cdc.gov/view/cdc/56923/cdc_56923_DS1.pdf
File Type:

[PDF - 1.30 MB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.