A systematic review and meta‐analysis of venous thrombosis risk among users of combined oral contraception
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

A systematic review and meta‐analysis of venous thrombosis risk among users of combined oral contraception

Filetype[PDF-772.30 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Int J Gynaecol Obstet
    • Personal Author:
    • Description:
      Background

      Combined oral contraceptives (COCs) containing various progestogens could be associated with differential risks for venous thromboembolism (VTE).

      Objective

      To evaluate the comparative risks of VTE associated with the use of low‐dose (less than 50 μg ethinyl estradiol) COCs containing different progestogens.

      Search strategy

      PubMed and the Cochrane Library were searched from database inception through September 15, 2016, by combining search terms for oral contraception and venous thrombosis.

      Selection criteria

      Studies reporting VTE risk estimates among healthy users of progestogen‐containing low‐dose COCs were included.

      Data collection and analysis

      A random‐effects model was used to generate pooled adjusted risk ratios and 95% confidence intervals; subgroup and sensitivity analyses assessed the impact of monophasic‐COC use and study‐level characteristics.

      Main results

      There were 22 articles included in the analysis. The use of COCs containing cyproterone acetate, desogestrel, drospirenone, or gestodene was associated with a significantly increased risk of VTE compared with the use of levonorgestrel‐containing COCs (pooled risk ratios 1.5–2.0). The analysis restricted to monophasic COC formulations with 30 μg of ethinyl estradiol yielded similar findings. After adjustment for study characteristics, the risk estimates were slightly attenuated.

      Conclusions

      Compared with the use of levonorgestrel‐containing COCs, the use of COCs containing other progestogens could be associated with a small increase in risk for VTE.

    • Subject:
    • Source:
      Int J Gynaecol Obstet. 141(3):287-294.
    • Pubmed ID:
      29388678
    • Pubmed Central ID:
      PMC5969307
    • Document Type:
      Journal Article
    • Funding:
      001/World Health Organization/International
    • Collection(s):
      CDC Public Access
    • Main Document Checksum:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov