Influenza D Virus Infection in Feral Swine Populations, United States

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ferguson, Lucas ; Luo, Kaijian ; Olivier, Alicia K. ; Cunningham, Fred L. ; Blackmon, Sherry ; Hanson-Dorr, Katie ; Sun, Hailiang ; Baroch, John ; Lutman, Mark W. ; Quade, Bianca ; Epperson, William ; Webby, Richard ; DeLiberto, Thomas J. ; Wan, Xiu-Feng
• Description:
  Influenza D virus (IDV) has been identified in domestic cattle, swine, camelid, and small ruminant populations across North America, Europe, Asia, South America, and Africa. Our study investigated seroprevalence and transmissibility of IDV in feral swine. During 2012-2013, we evaluated feral swine populations in 4 US states; of 256 swine tested, 57 (19.1%) were IDV seropositive. Among 96 archived influenza A virus-seropositive feral swine samples collected from 16 US states during 2010-2013, 41 (42.7%) were IDV seropositive. Infection studies demonstrated that IDV-inoculated feral swine shed virus 3-5 days postinoculation and seroconverted at 21 days postinoculation; 50% of in-contact naive feral swine shed virus, seroconverted, or both. Immunohistochemical staining showed viral antigen within epithelial cells of the respiratory tract, including trachea, soft palate, and lungs. Our findings suggest that feral swine might serve an important role in the ecology of IDV.
• Subjects:
  Animals Female Genotype Geography, Medical Hemagglutination Hemagglutination Tests Orthomyxoviridae Infections Public Health Surveillance Seroepidemiologic Studies Swine Swine Diseases Thogotovirus Viral Load Virus Shedding Zoonoses

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• Source:
  Emerg Infect Dis. 24(6):1020-1028.
• Pubmed ID:
  29774857
• Pubmed Central ID:
  PMC6004836
• Document Type:
  Journal Article
• Funding:
  R15 AI107702/AI/NIAID NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  24
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:606bbbef6451f80c5ee623ac5173b60a1ea3bcbfa9a13cf174fa39a40a1c8d65
• Download URL:
  https://stacks.cdc.gov/view/cdc/56334/cdc_56334_DS1.pdf
• File Type:
  [PDF - 3.18 MB ]