Use of Bead-Based Serologic Assay to Evaluate Chikungunya Virus Epidemic, Haiti

Rogier, Eric W.; Moss, Delynn M.; Mace, Kimberly E.; Chang, Michelle; Jean, Samuel E.; Bullard, Stevan M.; Lammie, Patrick J.; Lemoine, Jean Frantz; Udhayakumar, Venkatachalam

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Use of Bead-Based Serologic Assay to Evaluate Chikungunya Virus Epidemic, Haiti

Supporting Files Public Domain

Jun 2018
By Rogier, Eric W. ; Moss, Delynn M. ; Mace, Kimberly E. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Rogier, Eric W. ; Moss, Delynn M. ; Mace, Kimberly E. ; Chang, Michelle ; Jean, Samuel E. ; Bullard, Stevan M. ; Lammie, Patrick J. ; Lemoine, Jean Frantz ; Udhayakumar, Venkatachalam
Description:

The index case of chikungunya virus (CHIKV) in Haiti was reported during early 2014; the vector, the pervasive Aedes aegypti mosquito, promoted rapid spread throughout the country. During December 2014-February 2015, we collected blood samples from 4,438 persons at 154 sites (62 urban, 92 rural) throughout Haiti and measured CHIKV IgG by using a multiplex bead assay. Overall CHIKV seroprevalence was 57.9%; differences between rural (mean 44.9%) and urban (mean 78.4%) areas were pronounced. Logistic modeling identified the urban environment as a strong predictor of CHIKV exposure (adjusted odds ratio 3.34, 95% CI 2.38-4.69), and geographic elevation provided a strong negative correlation. We observed no correlation between age and antibody positivity or titer. Our findings demonstrated through serologic testing the recent and rapid dissemination of the arbovirus throughout the country. These results show the utility of serologic data to conduct epidemiologic studies of quickly spreading mosquitoborne arboviruses.
Subjects:

Adolescent Adult Aged Aged, 80 And Over Antibodies, Viral Antigens, Viral Chikungunya Fever Chikungunya Virus Child Child, Preschool Humans Immunoassay Immunoglobulin G Infant Microspheres Middle Aged Mosquito Vectors Population Surveillance Prevalence Rural Health Seroepidemiologic Studies Serologic Tests Urban Health Young Adult
Source:

Emerg Infect Dis. 24(6):995-1001.
Document Type:

Journal Article
Place as Subject:

Haiti
Volume:

24
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:238667bed00b27e597a7a43e100126cebc3f492d8c70fa2fcc439728f0e4f933f57da356ac6c7225126289201c6f50d0c679783b33885751cde0ad18bf8f404c
Download URL:

https://stacks.cdc.gov/view/cdc/56313/cdc_56313_DS1.pdf
File Type:

[PDF - 2.31 MB ]

File Language:

English

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