Epidemiology of Sapovirus Infections in a Birth Cohort in Peru

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Sánchez, Gerardo J ; Mayta, Holger ; Pajuelo, Monica J ; Neira, Karen ; Xiaofang, Liu ; Cabrera, Lilia ; Ballard, Sarah Blythe ; Crabtree, Jean E ; Kelleher, Dermot ; Cama, Vitaliano ; Bern, Caryn ; Oshitani, Hitoshi ; Gilman, Robert H ; Saito, Mayuko
• Corporate Authors:
  Sapovirus Working Group OchoaMayraVittetMacarenaPandoAlejandra
• Description:
  Background
  
  Sapovirus is one of the primary viral causes of acute gastroenteritis (AGE), especially where rotavirus vaccination has been implemented. The characteristics and impact of natural infection at the community level, however, have not been well documented.
  
  Methods
  
  Stool samples were analyzed from 100 children randomly selected from a community-based birth cohort study in Peru. All diarrheal and 1 nondiarrheal stools collected trimonthly from children up to age 2 years (n = 1669) were tested for sapovirus detection. Viral shedding duration was determined by testing additional weekly samples (n = 440) collected before and after a sapovirus-positive sample.
  
  Results
  
  The incidence of sapovirus infection in the first and second years of life was 4.3 and 11.1 per 100 child-months, respectively. By age 2 years, 82% of children had at least 1 sapovirus infection, and 64% had at least 1 sapovirus-associated diarrhea episode. The median shedding period was 18.5 days. In 112 of 175 infections, 14 genotypes from 4 genogroups (GI, GII, GIV, and GV) were determined. Among genogroups, GI were more frequently found in symptomatic infections than in asymptomatic infections (odds ratio, 3.1; 95% confidence interval, 1.3–7.4). Fifty-nine children had serial sapovirus infections, but only 3 had repeated infection of the same genotype.
  
  Conclusions
  
  Sapovirus was frequently detected in children with AGE at the community level during the first 2 years of life. Serial sapovirus infections by multiple genotypes in a child suggest genotype-specific immunity from each infection, which needs to be taken into account for vaccine development.
  
  
• Subjects:
  Caliciviridae Infections Cohort Studies Diarrhea Feces Female Gastroenteritis Genotype Humans Incidence Infant Infant, Newborn Male Phylogeny Public Health Sapovirus Virus Shedding

  More +
• Source:
  Clin Infect Dis. 2017; 66(12):1858-1863.
• Pubmed ID:
  29309577
• Pubmed Central ID:
  PMC5982808
• Document Type:
  Journal Article
• Funding:
  MR/K007467/1/Medical Research Council/United Kingdom ; R01 AI108695/AI/NIAID NIH HHS/United States
• Place as Subject:
  Peru
• Volume:
  66
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f62ddfbc405feea43eb9fde8934a61890e240544433208e39d2887e3e88d6eea
• Download URL:
  https://stacks.cdc.gov/view/cdc/55697/cdc_55697_DS1.pdf
• File Type:
  [PDF - 710.80 KB ]