Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007–2016

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Fox-Lewis, Andrew ; Takata, Junko ; Miliya, Thyl ; Lubell, Yoel ; Soeng, Sona ; Sar, Poda ; Rith, Kolthida ; McKellar, Gregor ; Wuthiekanun, Vanaporn ; McGonagle, Erin ; Stoesser, Nicole ; Moore, Catrin E. ; Parry, Christopher M. ; Turner, Claudia ; Day, Nicholas P.J. ; Cooper, Ben S. ; Turner, Paul
• Description:
  To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007-2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each of Escherichia coli and Klebsiella pneumoniae isolates were multidrug resistant. Hospital-acquired isolates were more often resistant than community-acquired isolates; resistance trends over time were heterogeneous. K. pneumoniae isolates from neonates were more likely than those from nonneonates to be resistant to ampicillin-gentamicin and third-generation cephalosporins. In patients with community-acquired gram-negative bacteremia, third-generation cephalosporin resistance was associated with increased mortality rates, increased intensive care unit admissions, and 2.26-fold increased healthcare costs among survivors. High antimicrobial resistance in this setting is a threat to human life and the economy. In similar low-resource settings, our methods could be reproduced as a robust surveillance model for antimicrobial resistance.
• Subjects:
  Anti-Bacterial Agents Bacterial Infections Child Child, Hospitalized Child, Preschool Community-Acquired Infections Cross Infection Drug Resistance, Bacterial Female Humans Infant Infant, Newborn Intensive Care Units Male Retrospective Studies Risk Factors Synopsis

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• Source:
  Emerg Infect Dis. 24(5):841-851
• Pubmed ID:
  29664370
• Pubmed Central ID:
  PMC5938766
• Document Type:
  Journal Article
• Funding:
  Wellcome Trust/United Kingdom ; MR/K006924/1/Medical Research Council/United Kingdom
• Place as Subject:
  Cambodia
• Location:
  Asia
• Volume:
  24
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6d9ea7fd7d08d088cc1ccfa0ada723431cd2b667c5a0076edd5ecf3f9be5e430
• Download URL:
  https://stacks.cdc.gov/view/cdc/54034/cdc_54034_DS1.pdf
• File Type:
  [PDF - 897.83 KB ]