Cerebrospinal Fluid Immunoglobulins as Potential Biomarkers of Chikungunya Encephalitis

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Puccioni-Sohler, Marzia ; Farias, Luiz Claudio ; Cabral-Castro, Mauro Jorge ; Zalis, Mariano G. ; Kalil, Rosangela S. ; Salgado, Maria Cecília F.
• Description:
  Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis. The specificity of the intracerebral immune response supports early chikungunya-associated encephalitis diagnosis.
• Subjects:
  Aged Anti-Inflammatory Agents Biomarkers Chikungunya Fever Cyclooxygenase Inhibitors Encephalitis, Viral Female Humans Immunoglobulins Prednisolone Sulfonamides

  More +
• Source:
  Emerg Infect Dis. 24(5):939-941
• Pubmed ID:
  29664389
• Pubmed Central ID:
  PMC5938764
• Document Type:
  Journal Article
• Genre:
  Letter
• Volume:
  24
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6ee0152ad5fc35f2641c0656084b4b6394e976b821de03b810e05016b2b424a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/54032/cdc_54032_DS1.pdf
• File Type:
  [PDF - 313.47 KB ]