Maternal Exposure to Radiographic Exams and Major Structural Birth Defects

Details

• Alternative Title:
  Birth Defects Res A Clin Mol Teratol
• Personal Author:
  Lim, Hyeyeun ; Beasley, Charles W. ; Whitehead, Lawrence W. ; Emery, Robert J. ; Agopian, A.J. ; Langlois, Peter H. ; Waller, Dorothy K.
• Corporate Authors:
  and the National Birth Defects Prevention Study
• Description:
  Background
  
  An increasing number of radiologic exams are performed in the United States, but very few studies have examined the effects of maternal exposure to radiologic exams during the periconceptional period and birth defects.
  
  Objectives
  
  To assess the association between maternal exposure to radiologic exams during the periconceptional period and 19 categories of birth defects using a large population-based study of birth defects. Methods: We studied 27,809 case mothers and 10,200 control mothers who participated in the National Birth Defects Prevention Study and delivered between 1997 and 2009. Maternal exposure to radiologic exams that delivered ionizing radiation to the urinary tract, lumbar spine, abdomen, or pelvis were identified based on the mother’s report of type of radiologic exams, organ or body part scanned and the month during which the exam occurred
  
  Results
  
  Overall, 0.9% of mothers reported exposure to one of these types of radiographic exams during the periconceptional period. We observed significant associations between maternal exposure during the first trimester and isolated Dandy-Walker malformation (odds ratio = 7.7; 95% confidence interval, 1.8–33) and isolated d-transposition of the great arteries (odds ratio = 3.8; 95% confidence interval, 1.4–10.3). However, the result for isolated Dandy-Walker malformation was based on only two exposed cases.
  
  Conclusion
  
  These results should be interpreted cautiously because multiple statistical tests were conducted and measurements of exposure were based on maternal report. However, our results may be useful for generating hypotheses for future studies.
  
  
• Keywords:
  Abnormalities, Radiation-Induced Adult Birth Defects Female Humans Isolated D-transposition Of The Great Arteries Maternal Exposure Pregnancy Radiography Radiography, Abdominal Retrospective Studies

  More +
• Source:
  Birth Defects Res A Clin Mol Teratol. 106(7):563-572
• Pubmed ID:
  27001904
• Pubmed Central ID:
  PMC5937123
• Document Type:
  Journal Article
• Funding:
  R03 OH010315/OH/NIOSH CDC HHSUnited States/ ; T42 OH008421/OH/NIOSH CDC HHSUnited States/ ; T42OH008421/ACL/ACL HHSUnited States/ ; U45 ES019360/ES/NIEHS NIH HHSUnited States/
• Volume:
  106
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a760738df8eb00ccb57f9d858a17f5c60a5c08c452a75270459f97049eaa7411
• Download URL:
  https://stacks.cdc.gov/view/cdc/53824/cdc_53824_DS1.pdf
• File Type:
  [PDF - 128.15 KB ]