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Maternal Exposure to Radiographic Exams and Major Structural Birth Defects



Details

  • Personal Author:
  • Corporate Authors:
    National Birth Defects Prevention Network
  • Description:
    Background: An increasing number of radiologic exams are performed in the United States, but very few studies have examined the effects of maternal exposure to radiologic exams during the periconceptional period and birth defects. Objectives: To assess the association between maternal exposure to radiologic exams during the periconceptional period and 19 categories of birth defects using a large population-based study of birth defects. Methods: We studied 27,809 case mothers and 10,200 control mothers who participated in the National Birth Defects Prevention Study and delivered between 1997 and 2009. Maternal exposure to radiologic exams that delivered ionizing radiation to the urinary tract, lumbar spine, abdomen, or pelvis were identified based on the mother's report of type of radiologic exams, organ or body part scanned and the month during which the exam occurred Results: Overall, 0.9% of mothers reported exposure to one of these types of radiographic exams during the periconceptional period. We observed significant associations between maternal exposure during the first trimester and isolated Dandy-Walker malformation (odds ratio 5 7.7; 95% confidence interval, 1.8-33) and isolated d-transposition of the great arteries (odds ratio 5 3.8; 95% confidence interval, 1.4-10.3). However, the result for isolated Dandy-Walker malformation was based on only two exposed cases. Conclusion: These results should be interpreted cautiously because multiple statistical tests were conducted and measurements of exposure were based on maternal report. However, our results may be useful for generating hypotheses for future studies. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1542-0752
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    106
  • NIOSHTIC Number:
    nn:20053859
  • Citation:
    Birth Defects Res A Clin Mol Teratol 2016 Jul; 106:563-572
  • Contact Point Address:
    Dorothy K. Waller, The University of Texas, UTHealth, School of Public Health, 1200 Pressler Street, E643 Houston, TX 77030
  • Email:
    kim.waller@uth.tmc.edu
  • Federal Fiscal Year:
    2016
  • Performing Organization:
    University of Texas Health Science Center, Houston
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    Birth Defects Research Part A: Clinical and Molecular Teratology
  • End Date:
    20250630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:6b53a792c42ef46a2bbeb1205285b682f0ce93a745869e3cbc0de13bf3834f8def72220dd8ee1c07d9a56419b6902de662040457b04534f816e2faaea8d76d9f
  • Download URL:
  • File Type:
    Filetype[PDF - 98.94 KB ]
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