Seasonal Incidence of Symptomatic Influenza in the United States
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Seasonal Incidence of Symptomatic Influenza in the United States

Filetype[PDF-270.12 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Clin Infect Dis
    • Personal Author:
    • Description:
      Background

      The seasonal incidence of influenza is often approximated as 5%–20%.

      Methods

      We used 2 methods to estimate the seasonal incidence of symptomatic influenza in the United States. First, we made a statistical estimate extrapolated from influenza-associated hospitalization rates for 2010–2011 to 2015–2016, collected as part of national surveillance, covering approximately 9% of the United States, and including the existing mix of vaccinated and unvaccinated persons. Second, we performed a literature search and meta-analysis of published manuscripts that followed cohorts of subjects during 1996–2016 to detect laboratory-confirmed symptomatic influenza among unvaccinated persons; we adjusted this result to the US median vaccination coverage and effectiveness during 2010–2016.

      Results

      The statistical estimate of influenza incidence among all ages ranged from 3.0%–11.3% among seasons, with median values of 8.3% (95% confidence interval [CI], 7.3%–9.7%) for all ages, 9.3% (95% CI, 8.2%–11.1%) for children <18 years, and 8.9% (95% CI, 8.2%–9.9%) for adults 18–64 years. Corresponding values for the meta-analysis were 7.1% (95% CI, 6.1%–8.1%) for all ages, 8.7% (95% CI, 6.6%–10.5%) for children, and 5.1% (95% CI, 3.6%–6.6%) for adults.

      Conclusions

      The 2 approaches produced comparable results for children and persons of all ages. The statistical estimates are more versatile and permit estimation of season-to-season variation. During 2010–2016, the incidence of symptomatic influenza among vaccinated and unvaccinated US residents, including both medically attended and nonattended infections, was approximately 8% and varied from 3% to 11% among seasons.

    • Subject:
    • Source:
      Clin Infect Dis. 66(10):1511-1518
    • Pubmed ID:
      29206909
    • Pubmed Central ID:
      PMC5934309
    • Document Type:
      Journal Article
    • Funding:
      CC999999/Intramural CDC HHS/United States
    • Name as Subject:
      Centers for Disease Control and Prevention (U.S.)
    • Place as Subject:
      United States
    • Collection(s):
      CDC Public Access
    • Main Document Checksum:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov