The disconnect between a national tuberculosis drug resistance survey and treatment outcomes: a lost opportunity

Details

• Alternative Title:
  Int J Tuberc Lung Dis
• Personal Author:
  Click, E. S. ; Chirenda, J. ; Kibias, S. ; Menzies, H. J. ; Oeltmann, J. E. ; Sentle, C. ; Muribe, T. ; Lere, T. D. ; Makombe, R. ; Bamrah, S. ; Moore, B. K. ; Cain, K. P.
• Description:
  We linked results from the Fourth Botswana National Drug Resistance Survey (DRS), 2007-2008, to patient records from the national Electronic Tuberculosis Registry to determine treatment outcomes. Of 915 new patients, 651 (71%) had treatment data available. Completion or cure was achieved for 10/15 (67%, 95%CI 42-85) with isoniazid monoresistance, (6/16, 38%, 95%CI 18-61) with multidrug resistance, while 73% (391/537, 95%CI 69-76) were susceptible to first-line drugs. The analysis was limited because of unavailable treatment records and undocumented outcomes. Prospective analyses following DRSs should be considered to ensure adequate outcome data.
• Subjects:
  Antitubercular Agents Botswana Female Follow-Up Studies Humans Isoniazid Male Mycobacterium Tuberculosis Registries Retrospective Studies Treatment Outcome Tuberculosis, Multidrug-Resistant

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• Keywords:
  Drug Outcome Resistance Survey Treatment
• Source:
  Int J Tuberc Lung Dis. 18(11):1319-1322
• Pubmed ID:
  25299864
• Pubmed Central ID:
  PMC5931357
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  18
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9d1799972c14fc9913b610d4411887774e7b6a2840a9a21c3d56ff8261e76600
• Download URL:
  https://stacks.cdc.gov/view/cdc/53783/cdc_53783_DS1.pdf
• File Type:
  [PDF - 239.87 KB ]