Unmasking molecular profiles of bladder cancer

Details

• Alternative Title:
  Investig Clin Urol
• Personal Author:
  Piao, Xuan-Mei ; Byun, Young Joon ; Kim, Wun-Jae ; Kim, Jayoung
• Description:
  Precision medicine is designed to tailor treatments for individual patients by factoring in each person's specific biology and mechanism of disease. This paradigm shifted from a "one size fits all" approach to "personalized and precision care" requires multiple layers of molecular profiling of biomarkers for accurate diagnosis and prediction of treatment responses. Intensive studies are also being performed to understand the complex and dynamic molecular profiles of bladder cancer. These efforts involve looking bladder cancer mechanism at the multiple levels of the genome, epigenome, transcriptome, proteome, lipidome, metabolome etc. The aim of this short review is to outline the current technologies being used to investigate molecular profiles and discuss biomarker candidates that have been investigated as possible diagnostic and prognostic indicators of bladder cancer.
• Subjects:
  Biomarkers Liquid Biopsy Precision Medicine Review Article Urinary Bladder Neoplasms
• Source:
  Investig Clin Urol. 2018; 59(2):72-82.
• Pubmed ID:
  29520382
• Pubmed Central ID:
  PMC5840121
• Document Type:
  Journal Article
• Funding:
  U01 DK103260/DK/NIDDK NIH HHS/United States ; U01 DP006079/DP/NCCDPHP CDC HHS/United States
• Volume:
  59
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:27159a56c2dddfb01e227a13e016ce8591e473c86b6abc7aac25ecd18c587c65
• Download URL:
  https://stacks.cdc.gov/view/cdc/53655/cdc_53655_DS1.pdf
• File Type:
  [PDF - 365.55 KB ]