Unmasking molecular profiles of bladder cancer

Piao, Xuan-Mei; Byun, Young Joon; Kim, Wun-Jae; Kim, Jayoung

doi:10.4111/icu.2018.59.2.72

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Unmasking molecular profiles of bladder cancer

Published Date:

Feb 01 2018

Publisher's site:

http://dx.doi.org/10.4111/icu.2018.59.2.72 New Site Icon

Source:

Investig Clin Urol. 2018; 59(2):72-82.

[PDF-365.55 KB]

Details:

Personal Authors:

Piao, Xuan-Mei ; Byun, Young Joon ; Kim, Wun-Jae ; Kim, Jayoung ;

Keywords:

[+]

Pubmed ID:

29520382

Pubmed Central ID:

PMC5840121

Description:

Precision medicine is designed to tailor treatments for individual patients by factoring in each person's specific biology and mechanism of disease. This paradigm shifted from a "one size fits all" approach to "personalized and precision care" requires multiple layers of molecular profiling of biomarkers for accurate diagnosis and prediction of treatment responses. Intensive studies are also being performed to understand the complex and dynamic molecular profiles of bladder cancer. These efforts involve looking bladder cancer mechanism at the multiple levels of the genome, epigenome, transcriptome, proteome, lipidome, metabolome etc. The aim of this short review is to outline the current technologies being used to investigate molecular profiles and discuss biomarker candidates that have been investigated as possible diagnostic and prognostic indicators of bladder cancer.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

U01 DK103260/DK/NIDDK NIH HHS/United States
U01 DP006079/DP/NCCDPHP CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

	icu-59-72-g001.gif	image/gif
	icu-59-72-g001.jpg	image/jpeg
	icu-59-72.nxml	text/xml

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