Unmasking molecular profiles of bladder cancer

Piao, Xuan-Mei; Byun, Young Joon; Kim, Wun-Jae; Kim, Jayoung

doi:10.4111/icu.2018.59.2.72

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Unmasking molecular profiles of bladder cancer

Published Date:

Feb 01 2018

Publisher's site:

http://dx.doi.org/10.4111/icu.2018.59.2.72 New Site Icon

Source:

Investig Clin Urol. 2018; 59(2):72-82.

[PDF-365.55 KB]

Details:

Personal Authors:

Piao, Xuan-Mei ; Byun, Young Joon ; Kim, Wun-Jae ; Kim, Jayoung ;

Keywords:

[+]

Pubmed ID:

29520382

Pubmed Central ID:

PMC5840121

Description:

Precision medicine is designed to tailor treatments for individual patients by factoring in each person's specific biology and mechanism of disease. This paradigm shifted from a "one size fits all" approach to "personalized and precision care" requires multiple layers of molecular profiling of biomarkers for accurate diagnosis and prediction of treatment responses. Intensive studies are also being performed to understand the complex and dynamic molecular profiles of bladder cancer. These efforts involve looking bladder cancer mechanism at the multiple levels of the genome, epigenome, transcriptome, proteome, lipidome, metabolome etc. The aim of this short review is to outline the current technologies being used to investigate molecular profiles and discuss biomarker candidates that have been investigated as possible diagnostic and prognostic indicators of bladder cancer.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

U01 DK103260/DK/NIDDK NIH HHS/United States
U01 DP006079/DP/NCCDPHP CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

	icu-59-72-g001.gif	image/gif
	icu-59-72-g001.jpg	image/jpeg
	icu-59-72.nxml	text/xml

No Related Documents.

You May Also Like:

Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases

Personal Author:

Chen, Zhaohui; Kim, Jayoung;

Published:

Mar 22 2016

Source:

BMC Urol. 16.

Description:

Background : Assays of molecular biomarkers in urine are non-invasive compared to other body fluids and can be easily repeated. Based on the hypothesis that the secreted markers from the diseased organs may locally release into the body fluid in the ...

File Type:

[PDF - 1.04 MB]
In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.

Personal Author:

Nussbaum, M; Fiala, E S; Kulkarni, B; El-Bayoumy, K; Weisburger, J H;

Published:

Mar 1983

Source:

Environ Health Perspect. 49:223-231.

Description:

The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the main lesion...

File Type:

[PDF - 1.21 MB]
Quantitative Proteomic Analysis Reveals Caffeine-Perturbed Proteomic Profiles in Normal Bladder Epithelial Cells

Personal Author:

Shahid, Muhammad; Kim, Minhyung; Yeon, Austin; Andres, Allen M.; You, Sungyong; Kim, Jayoung;

Published:

October 11 2018

Source:

Proteomics. 18(20):e1800190

Description:

Lower urinary tract symptoms (LUTSs) are highly prevalent among the elderly and negatively impact quality of life. Since caffeinated beverages are enjoyed worldwide and the relationship between LUTS and caffeine is still not fully understood, it woul...

Public Access
Available on:

October 11, 2019
Enzymatic Oxidative Biodegradation of Nanoparticles: Mechanisms, Significance and Applications

Personal Author:

Vlasova, Irina I.; Kapralov, Alexandr A.; Michael, Zachary P.; Burkert, Seth C.; Shurin, Michael R.; Star, Alexander; Shvedova, Anna A.; Kagan, Valerian E.;

Published:

Jan 06 2016

Source:

Toxicol Appl Pharmacol. 299:58-69.

Description:

Biopersistence of carbon nanotubes, graphene oxide (GO) and several other types of carbonaceous nanomaterials is an essential determinant of their health effects. Successful biodegradation is one of the major factors defining the life span and biolog...

File Type:

[PDF - 2.36 MB]
Addendum to the Toxicological profile for benzidine

Corporate Author:

United States. Agency for Toxic Substances and Disease Registry. Division of Toxicology and Environmental Medicine.

Published:

September 2009

Description:

cdc:6478 : This addendum for Benzidine supplements the Toxicological Profile for Benzidine that was released in 2001. : Toxicological profiles are developed in response to the Superfund Amendments and Reauthorization Act (SARA) of 1986, which amended...

File Type:

[PDF - 287.55 KB]