Details:

Alternative Title:
Paediatr Perinat Epidemiol
Personal Author:
Marcotte, Erin L ; Druley, Todd E ; Johnson, Kimberly J ; Richardson, Michaela ; von Behren, Julie ; ... More +
Marcotte, Erin L ; Druley, Todd E ; Johnson, Kimberly J ; Richardson, Michaela ; von Behren, Julie ; Mueller, Beth A ; Carozza, Susan ; McLaughlin, Colleen ; Chow, Eric J ; Reynolds, Peggy ; Spector, Logan G Less -
Description:
Background

Infant leukemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL etiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL.

Methods

We evaluated the relationship between parental age and IL in a case-control study using registry data from New York, Minnesota, California, Texas and Washington. Records from 402 cases (219 acute lymphoblastic leukemia [ALL], 131 acute myeloid leukemia [AML], 52 other) and 45,392 controls born during 1981–2004 were analyzed. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively.

Results

Infants with mothers age ≥40 years had an increased risk of developing AML (OR 4.80, 95% CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95% CI 1.62, 8.41).

Conclusion

Ours is the first study to show an association with young paternal age and infant ALL. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations and/or carcinogenic exposures may be involved in IL etiology.


Subjects:
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Article Childhood Cancer Epidemiology Infant Leukemia Maternal Age Paternal Age
Source:
Paediatr Perinat Epidemiol. 31(6):563-572.
Pubmed ID:
28940632
Pubmed Central ID:
PMC5901723
Document Type:
Journal Article
Funding:
N01 CN005230/CN/NCI NIH HHS/United States ; R01 CA092670/CA/NCI NIH HHS/United States ; U58 DP000783/DP/NCCDPHP CDC HHS/United States
N01 CN005230/CN/NCI NIH HHS/United States ; R01 CA092670/CA/NCI NIH HHS/United States ; U58 DP000783/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a69d3c1c3ee187422b9fd87f48411361fb6eaf2e617e437d5cfdb77a56fa5ea2
Download URL:
https://stacks.cdc.gov/view/cdc/53503/cdc_53503_DS1.pdf
File Type:

Supporting Files

• 	NIHMS951654-supplement-Supplementary_Tables.docx	docx
  	nihms951654.nxml	xml
  	nihms951654f1.gif	gif
  	nihms951654f1.jpg	jpeg
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  	nihms951654f2.jpg	jpeg

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