Details:

Alternative Title:
J Infect Dis
Personal Author:
Thompson, Mark G. ; Breiman, Robert F. ; Hamel, Mary J. ; Desai, Meghna ; Emukule, Gideon ; ... More +
Thompson, Mark G. ; Breiman, Robert F. ; Hamel, Mary J. ; Desai, Meghna ; Emukule, Gideon ; Khagayi, Sammy ; Shay, David K. ; Morales, Kathleen ; Kariuki, Simon ; Bigogo, Godfrey M. ; Njenga, M. Kariuki ; Burton, Deron C. ; Odhiambo, Frank ; Feikin, Daniel R. ; Laserson, Kayla F. ; Katz, Mark A. Less -
Description:
Background

Although children <5 years old in sub-Saharan Africa are vulnerable to both malaria and influenza, little is known about coinfection.

Methods

This retrospective, cross-sectional study in rural western Kenya examined outpatient visits and hospitalizations associated with febrile acute respiratory illness (ARI) during a 2-year period (July 2009–June 2011) in children <5 years old.

Results

Across sites, 45% (149/331) of influenza-positive patients were coinfected with malaria, whereas only 6% (149/2408) of malaria-positive patients were coinfected with influenza. Depending on age, coinfection was present in 4%–8% of outpatient visits and 1%–3% of inpatient admissions for febrile ARI. Children with influenza were less likely than those without to have malaria (risk ratio [RR], 0.57–0.76 across sites and ages), and children with malaria were less likely than those without to have influenza (RR, 0.36–0.63). Among coinfected children aged 24–59 months, hospital length of stay was 2.7 and 2.8 days longer than influenza-only-infected children at the 2 sites, and 1.3 and 3.1 days longer than those with malaria only (all P < .01).

Conclusions

Coinfection with malaria and influenza was uncommon but associated with longer hospitalization than single infections among children 24–59 months of age.


Subject:
[+]
Article
Child, Preschool
Female
HIV Infections
Hospitalization
Humans
Infant
Infant, Newborn
Influenza, Human
Malaria
Male
Risk Factors

Source:
J Infect Dis. 206(11):1674-1684.
Pubmed ID:
22984118
Pubmed Central ID:
PMC5901689
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; U19 CI000323/CI/NCPDCID CDC HHS/United States ; 5U19CI000323-05/CI/NCPDCID CDC HHS/United States
CC999999/Intramural CDC HHS/United States ; U19 CI000323/CI/NCPDCID CDC HHS/United States ; 5U19CI000323-05/CI/NCPDCID CDC HHS/United States Less -
Place as Subject:
Kenya
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:95755499f64d2c9703bf982e7345b78eb459727cd52e283002248e037781535f
File Type:

Supporting Files

• 	NIHMS949615-supplement-Suppl_Table_A.doc	doc
  	nihms949615.nxml	xml
  	nihms949615f1.gif	gif
  	nihms949615f1.jpg	jpeg
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  	nihms949615f2.jpg	jpeg

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